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Type: Artigo de periódico
Title: Eicosapentaenoic acid decreases TNF-alpha and protects dystrophic muscles of mdx mice from degeneration
Author: Machado, RV
Mauricio, AF
Taniguti, APT
Ferretti, R
Neto, HS
Marques, MJ
Abstract: In dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy, inflammation and increased production of tumor necrosis factor alpha (TNF-alpha) contribute to myonecrosis. We examined the effects of eicosapentaenoic acid (EPA) on dystrophic muscle degeneration. Mdx mice (14 days old) received EPA for 16 days. The sternomastoid, diaphragm and biceps brachii muscles were removed. Control mdx mice received vehicle. EPA decreased creatine kinase and myonecrosis and reduced the levels of TNF-alpha. These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-alpha, and support further investigations of EPA as a potential therapy for dystrophinopathies. (C) 2010 Elsevier B.V. All rights reserved.
Subject: EPA
Duchenne dystrophy
mdx mice
Muscle degeneration
Sarcolemma leakiness
Country: Holanda
Editor: Elsevier Science Bv
Citation: Journal Of Neuroimmunology. Elsevier Science Bv, v. 232, n. 41671, n. 145, n. 150, 2011.
Rights: fechado
Identifier DOI: 10.1016/j.jneuroim.2010.10.032
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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