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Type: Artigo de periódico
Title: Efficient Heck arylations of cyclic and acyclic acrylate derivatives using arenediazonium tetrafluoroborates. A new synthesis of the antidepressant drug (+/-)-paroxetine
Author: Pastre, JC
Correia, CRD
Abstract: The Heck arylation of acyclic- and cyclic-substituted acrylates using several arenediazonium tetrafluoroborates was investigated. Arylations were carried out under aerobic, ligand-free conditions to provide the corresponding substituted acrylates in moderate to high isolated yields. Heck arylations were usually completed in less than 2 h in refluxing methanol. The aza-endocyclic acrylate derivative 11a was converted into the antidepressant drug ((+)(-))-paroxetine in a concise new route in good overall yield.
Country: EUA
Editor: Amer Chemical Soc
Citation: Organic Letters. Amer Chemical Soc, v. 8, n. 8, n. 1657, n. 1660, 2006.
Rights: fechado
Identifier DOI: 10.1021/ol060248e
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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