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Type: Artigo de periódico
Title: Neutrophil migration induced by staphylococcal enterotoxin type A in mice: a pharmacological analysis
Author: Desouza, IA
Ribeiro-DaSilva, G
Abstract: Staphylococcal enterotoxin type A induced marked neutrophil migration into the mouse peritoneal cavity and was dependent on the number of resident macrophages. This migratory response was dose- (16-64 mu g of staphylococcal enterotoxin type A/cavity) and time-dependent, peaking at 12 h and disappearing after 72 h. Dexamethasone (0.5 mg/kg) inhibited the neutrophil migration induced by staphylococcal enterotoxin type A (32 mu g; 42% inhibition). A similar response was observed with the platelet-activating factor-acether receptor antagonist, BN 52021 (ginkgolide B, 3-(1,1-dimethylethyl)-hexahydro-1,4-7b-trihydroxy-8-methyl-9H-1,7 alpha (epoxymethanol 1H,6 alpha H-cyclopenta (c) furo (2,3-b) furo (3', 2': 3,4) cyclopenta (1,2-d) furan-5, 9, 12 (4H)-trione); 10 mg/kg; 57% inhibition), the histamine H-2 receptor antagonist, cimetidine (2 mg/kg; 31% inhibition), the lipoxygenase inhibitor, BWA4C (N-(3-phenoxycinnamyl) acetohydroxamic acid); 10 mg/kg; 73% inhibition), and capsaicin (trans-8-methyl-N-vanilyl-6-nonamide), a sensory C-fiber neuropeptide depletor. In contrast, indomethacin (5 mg/kg) had no effect on staphylococcal enterotoxin type A-induced chemotaxis. We conclude that the peritonitis induced by staphylococcal enterotoxin type A in mice is macrophage-dependent. The mechanism whereby staphylococcal enterotoxin type A stimulates macrophages to induce neutrophil recruitment remains to be elucidated. (C) 1998 Elsevier Science B.V. All rights reserved.
Subject: staphylococcal enterotoxin type A
staphylococcal enterotoxin type B
neutrophil migration
skin air-pouch
neurogenic inflammation
peritoneal cavity
Country: Holanda
Editor: Elsevier Science Bv
Citation: European Journal Of Pharmacology. Elsevier Science Bv, v. 363, n. 41700, n. 189, n. 195, 1998.
Rights: fechado
Identifier DOI: 10.1016/S0014-2999(98)00805-X
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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