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Type: Artigo de periódico
Title: Neuropathy of Gastrointestinal Chagas' Disease: Immune Response to Myelin Antigens
Author: Oliveira, EC
Fujisawa, MM
Longo, DEMH
Farias, AS
Moraes, JC
Guariento, ME
de Almeida, EA
Saad, MJA
Langone, F
Toyama, MH
Andreollo, NA
Santos, LMB
Abstract: Most reports of autoimmune response during infection with the parasite Trypanosoma cruzi have dealt with the cardiomyopathic form of Chagas' disease, but little is known about the mechanisms of tissue damage involved in the gastrointestinal form, which was studied here. Chronically infected patients with a severe gastrointestinal form of Chagas' disease present increased antibody production and proliferative responses to peripheral myelin components, such as myelin basic protein (MBP), which is homologous to the P1 protein fraction of peripheral myelin. T lymphocytes preferentially recognize a region on the MBP molecule (1-30), which suggests that the MBP is a potential target on the peripheral nerve for autoimmune reactions in patients with gastrointestinal lesions resulting from Chagas' disease. Copyright (C) 2008 S. Karger AG, Basel
Subject: Myelin basic protein
Trypanosoma cruzi
Country: Suíça
Editor: Karger
Citation: Neuroimmunomodulation. Karger, v. 16, n. 1, n. 54, n. 62, 2009.
Rights: fechado
Identifier DOI: 10.1159/000179667
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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