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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleNeuroanatomical Correlates of Depression in Friedreich's Ataxia: a Voxel-Based Morphometry Studypt_BR
dc.contributor.authorda Silva, CBpt_BR
dc.contributor.authorYasuda, CLpt_BR
dc.contributor.authorD'Abreu, Apt_BR
dc.contributor.authorCendes, Fpt_BR
dc.contributor.authorLopes-Cendes, Ipt_BR
dc.contributor.authorFranca, MCpt_BR
unicamp.author.emailmcfrancajr@uol.com.brpt_BR
unicamp.authorda Silva, Cynthia B. Yasuda, Clarissa L. D'Abreu, Anelyssa Cendes, Fernando Franca, Marcondes C., Jr. Univ Campinas UNICAMP, Dept Neurol, BR-13083887 Campinas, SP, Brazilpt_BR
unicamp.authorda Silva, Cynthia B. Yasuda, Clarissa L. D'Abreu, Anelyssa Cendes, Fernando Franca, Marcondes C., Jr. Univ Campinas UNICAMP, Neuroimaging Lab, BR-13083887 Campinas, SP, Brazilpt_BR
unicamp.authorLopes-Cendes, Iscia Univ Campinas UNICAMP, Fac Med, BR-13083887 Campinas, SP, Brazilpt_BR
dc.subjectFriedreich's ataxiapt_BR
dc.subjectDepressionpt_BR
dc.subjectMRIpt_BR
dc.subjectVoxel-based morphometrypt_BR
dc.subject.wosGray-matter Reductionpt_BR
dc.subject.wosQuality-of-lifept_BR
dc.subject.wosParkinsons-diseasept_BR
dc.subject.wosUnipolar Depressionpt_BR
dc.subject.wosMolecular-geneticspt_BR
dc.subject.wosClinical-featurespt_BR
dc.subject.wosCognitive Controlpt_BR
dc.subject.wosDisorderpt_BR
dc.subject.wosMetaanalysispt_BR
dc.subject.wosVolumept_BR
dc.description.abstractAffective disorders have been increasingly recognized in neurodegenerative diseases and often result in poor quality of life. However, the frequency, clinical relevance, and anatomical substrate of depression in Friedreich's ataxia were not yet evaluated. We assessed 22 patients with Friedreich's ataxia for major depression using Beck Depression Inventory and cerebral 3 T MRI scans. We then employed whole-brain voxel-based morphometry analyses on volumetric T1 datasets to compare tissue loss between patients with and without major depression. Patients (36.3 %) fulfilled criteria for major depression (8/22). Mean Beck Depression Inventory (BDI) score was 9.63 +/- 8.95 and the depressive group had significantly higher score compared to non-depressive group (18.5 +/- 8.6 vs 4.4 +/- 2.9, p < 0.001). There was no correlation between Beck Depression Inventory score and age of patients, ataxia severity, age at onset, or duration of the disease. The comparison between patient groups found no significant differences of white matter volumes. In contrast, we found reduction of gray matter volumes in the depressive group in medial and orbital region of frontal lobe and anterior cingulate gyri (p < 0.001). Regression analyses have shown that BDI scores were inversely correlated with gray matter volume at right superior frontal gyrus. Major depression is frequent in Friedreich's ataxia and possibly under recognized. Our results strongly suggest that this may not be a simply reactive phenomenon, but rather associated to structural abnormalities.pt
dc.relation.ispartofCerebellumpt_BR
dc.relation.ispartofabbreviationCerebellumpt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherSpringerpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationCerebellum. Springer, v. 12, n. 3, n. 429, n. 436, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume12pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage429pt_BR
dc.description.lastpage436pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1473-4222pt_BR
dc.identifier.wosidWOS:000318445000025pt_BR
dc.identifier.doi10.1007/s12311-012-0424-0pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-07-30T17:23:48Z
dc.date.available2015-11-26T16:37:46Z-
dc.date.accessioned2014-07-30T17:23:48Z
dc.date.accessioned2015-11-26T16:37:46Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T17:23:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:37:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65273
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65273-
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