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Type: Artigo de periódico
Title: Electrochemical evaluation of rhodium dimer-DNA interactions
Author: Gil, ED
Serrano, SHP
Ferreira, EI
Kubota, LT
Abstract: The interaction of rhodium dimers, including the carboxylates (acetate, propionate, butyrate, trifluoroacetate, citrate and gluconate), amidates (acetamidate and trifluoroacetamidate) and carboxamidate (Doyle catalyst S) with DNA was investigated by electrochemical methods. Differential pulse voltammetry measurements showed, in agreement to literature data, that most of rhodium carboxylates have a higher affinity for adenine than guanine residues. Some differences of reactivity may be correlated with the compound structures and these were helpful in understanding the influence of equatorial ligands on axial coordination mechanisms. The preliminary results might be extended for further studies on quantitative structure activity relationship approaches, highlighting electrochemical methods as a tool for this purpose. (C) 2002 Elsevier Science B.V. All rights reserved.
Subject: DNA-interactions
rhodium complexes
structure-activity relationship
carbon fiber electrode
Country: Holanda
Editor: Elsevier Science Bv
Citation: Journal Of Pharmaceutical And Biomedical Analysis. Elsevier Science Bv, v. 29, n. 4, n. 579, n. 584, 2002.
Rights: fechado
Identifier DOI: 10.1016/S0731-7085(01)00700-2
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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