Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65119
Type: Artigo de periódico
Title: Effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndromes: Induction of IL-10 expression in the stromal layers
Author: Lazarini, M
Traina, F
Winnischofer, SM
Costa, FF
Queiroz, MLS
Saad, STO
Abstract: The purpose of this study was to investigate the in vitro effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndrome. We demonstrated that thalidomide induced an increase in granulocyte-macrophage colony forming unit numbers and in IL-10 expression. Thalidomide also promoted a slight increase in IL-6, IL-1 beta and TNF-alpha expression in the stromal layers. The numbers of erythroid burst forming units, the apoptosis rate of hematopoietic cells, and VEGF and TNF-alpha expression levels in culture supernatants were not modulated. Our results indicate a participation of thalidomide upon the hematopoietic microenvironment of patients with myelodysplastic syndromes, especially in the up regulation of IL-10. (C) 2011 Elsevier Ltd. All rights reserved.
Subject: Myelodysplastic syndromes
Bone marrow microenvironment
Thalidomide
Cytokines
Interleukin-10
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2011.03.027
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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