Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65078
Type: Artigo de periódico
Title: Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats
Author: de Faria, FM
Luiz-Ferreira, A
Socca, EAR
de Almeida, ACA
Dunder, RJ
Manzo, LP
da Silva, MA
Vilegas, W
Rozza, AL
Pellizzon, CH
dos Santos, LC
Brito, ARMS
Abstract: Male Unib-WH rats were pretreated for two weeks with butanolic (BuOH) and ethyl acetate (EtOAc) fractions. Colitis was induced by rectal administration of TNBS, the treatment continued, and animals were sacrificed on day 7 after the TNBS administration. Phytochemical studies were performed in order to provide the characterization of the tannins present in the bark of R. mangle. Results showed that EtOAc fraction increased the levels of IL-10 (** P < 0.01) and diminished the levels of TNF-alpha (*** P < 0.001) and IL-6 (** P < 0.01). BuOH fraction reduced the MPO activity (** P < 0.01) and levels of TBARS (*** P < 0.001); it also increased COX-1 expression, diminished the levels of TNF-alpha (*** P < 0.001), and increased the levels of IL-12 (*** P < 0.001). Besides, both treatments augmented the levels of GSH (* P < 0.05), the activity of GSH-Px (** P < 0.01 for BuOH fraction and *** P < 0.001 for EtOAc fraction), and CAT (** P < 0.01). In conclusion, both treatments ameliorated the injury induced by TNBS through different mechanisms, probably by their chemical composition which directed its activity into an antioxidant or anti-inflammatory response, leading to an immune modulation.
Country: EUA
Editor: Hindawi Publishing Corporation
Rights: aberto
Identifier DOI: 10.1155/2012/753971
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000309542000001.pdf2.52 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.