Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/65021
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAparicio, Ricardopt_BR
dc.contributor.authorunicampSimioni, Lea Rodriguespt_BR
dc.contributor.authorunicampCamargo, Enilton Aparecidopt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.contributor.authorunicampToyoma, Daniela de Oliveirapt_BR
dc.contributor.authorunicampMarangoni, Sérgiopt_BR
dc.contributor.authorunicampToyama, Marcos Hikaript_BR
dc.typeArtigopt_BR
dc.titleEffects of morin on snake venom phospholipase A(2) (PLA(2))pt_BR
dc.title.alternativeen
dc.contributor.authorAparicio, R.pt_BR
dc.contributor.authorMonteiro, H.S.A.pt_BR
dc.contributor.authorRodrigues-Simioni, L.pt_BR
dc.contributor.authorBeriam, L.O.S.pt_BR
dc.contributor.authorCamargo, E.A.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorToyoma, D.D.pt_BR
dc.contributor.authorMarangoni, S.pt_BR
dc.contributor.authorToyama, M.H.pt_BR
dc.contributor.authorIglesias, C.V.pt_BR
unicamp.author.emailmhtjpn@yahoo.compt_BR
unicamp.authorUniv Sao Vicente, CLP, UNESP, Sao Vicente, SP, Brazil Inst Biol, Dept Bioquim, Campinas, SP, Brazil Inst Quim, Campinas, SP, Brazil UNICAMP, Fac Med, Dept Farmacol, Campinas, SP, Brazil Univ Presbiteriana Mackenzie, Fac Ciencias Biol Exatas & Expt, Campinas, SP, Brazil UFC, Dept Farmacol, Fortaleza, Ceara, Brazil Inst Biol Campinas, Ctr Expt, Lab Bacteriol Vegetal, Campinas, SP, Brazilpt_BR
dc.subjectFlavonóidespt_BR
dc.subjectSequência de aminoácidospt_BR
dc.subjectDicroísmo circularpt_BR
dc.subject.otherlanguageFlavonoidspt_BR
dc.subject.otherlanguageAmino acid sequencept_BR
dc.subject.otherlanguageCircular dichroismpt_BR
dc.subject.wosAntiinflammatory Activitypt_BR
dc.subject.wosGroup-iipt_BR
dc.subject.wosFlavonoidspt_BR
dc.subject.wosInhibitionpt_BR
dc.subject.wosInflammationpt_BR
dc.subject.wosAntioxidantpt_BR
dc.subject.wosProteinspt_BR
dc.subject.wosReleasept_BR
dc.subject.wosAssaypt_BR
dc.subject.wosAcidpt_BR
dc.description.abstractFlavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes. In this work, a PLA(2) isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to. study the effect of flavonoids on PLA(2). We observed that a treatment of PLA(2) with morin induces several modifications in the aromatic amino acids, with accompanying changes in its amino acid composition. In addition, results from circular dichroism spectroscopy and UV scanning revealed important structural modifications. Concomitantly, a considerable decrease in the enzymatic and antibacterial activities was observed, even though anti-inflammatory and neurotoxic activities were not affected. These apparent controversial results may be an indication that PLA(2) possess a second pharmacological site which does not affect or depend on the enzymatic activitypt
dc.description.eventPergamon Presspt_BR
dc.relation.ispartofToxiconpt_BR
dc.relation.ispartofabbreviationToxiconpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherPergamon-elsevier Science Ltdpt_BR
dc.date.issued2005pt_BR
dc.date.monthofcirculationDec.pt_BR
dc.identifier.citationToxicon. Pergamon-elsevier Science Ltd, v. 46, n. 7, n. 751, n. 758, 2005.pt_BR
dc.language.isoengpt_BR
dc.description.volume46pt_BR
dc.description.issuenumber7pt_BR
dc.description.issuesupplementpt_BR
dc.description.firstpage751pt_BR
dc.description.lastpage758pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWOSpt_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn0041-0101pt_BR
dc.identifier.eissnpt_BR
dc.identifier.wosidWOS:000233491400005pt_BR
dc.identifier.doi10.1016/j.toxicon.2005.07.017pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0041010105002680pt_BR
dc.description.sponsorshipFAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumber04/00040-3pt_BR
dc.date.available2014-11-17T21:10:48Z
dc.date.available2015-11-26T16:46:41Z-
dc.date.accessioned2014-11-17T21:10:48Z
dc.date.accessioned2015-11-26T16:46:41Z-
dc.description.provenanceMade available in DSpace on 2014-11-17T21:10:48Z (GMT). No. of bitstreams: 1 WOS000233491400005.pdf: 175030 bytes, checksum: 1d597104155b21dbfd5796ce13c7384b (MD5) Previous issue date: 2005en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:46:41Z (GMT). No. of bitstreams: 2 WOS000233491400005.pdf: 175030 bytes, checksum: 1d597104155b21dbfd5796ce13c7384b (MD5) WOS000233491400005.pdf.txt: 34434 bytes, checksum: d1821cb82d2c4f36fdc3e606e1f2d109 (MD5) Previous issue date: 2005en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65021pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/65021
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65021-
dc.description.conferencedateInglaterrapt_BR
dc.description.conferencelocationToxiconpt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Bioquímicapt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.description.abstractalternative-
dc.identifier.source000233491400005-
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.creator.orcid0000-0001-6836-3084pt_BR
dc.type.formArtigo original-
dc.description.eventsponsorOxfordpt_BR
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