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Type: Artigo
Title: Effects of morin on snake venom phospholipase A(2) (PLA(2))
Author: Aparicio, R.
Monteiro, H.S.A.
Rodrigues-Simioni, L.
Beriam, L.O.S.
Camargo, E.A.
Antunes, E.
Toyoma, D.D.
Marangoni, S.
Toyama, M.H.
Iglesias, C.V.
Abstract: Flavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes. In this work, a PLA(2) isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to. study the effect of flavonoids on PLA(2). We observed that a treatment of PLA(2) with morin induces several modifications in the aromatic amino acids, with accompanying changes in its amino acid composition. In addition, results from circular dichroism spectroscopy and UV scanning revealed important structural modifications. Concomitantly, a considerable decrease in the enzymatic and antibacterial activities was observed, even though anti-inflammatory and neurotoxic activities were not affected. These apparent controversial results may be an indication that PLA(2) possess a second pharmacological site which does not affect or depend on the enzymatic activity
Subject: Dicroísmo circular
Sequência de aminoácidos
Country: Reino Unido
Editor: Elsevier
Citation: Toxicon. Pergamon-elsevier Science Ltd, v. 46, n. 7, n. 751, n. 758, 2005.
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2005.07.017
Date Issue: 2005
Appears in Collections:IFGW - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

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