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|Type:||Artigo de periódico|
|Title:||Effects of Mikania genus plants on growth and cell adherence of mutans streptococci|
|Abstract:||The present study evaluated the chemical composition and the antimicrobial activity of the extracts and fractions of Mikania laevigata and Mikania glomerata on growth and cell adherence of mutans streptococci. Ethanolic extract, hexane and ethyl acetate fractions of Mikania laevigata and Mikania glomerata were chemically identified by chromatographic methods and tested on mutans streptococci front culture collection and clinical isolates. Twenty-two compounds were identified in both Mikania extracts, including coumarin, 1-octadecene, and diterpenic, cupressenic and kaurenoic acids. Antimicrobial activity was assessed by determination of the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibition of cell adherence to a glass surface. Hexane fraction from both plant extracts was the most effective in inhibiting the growth of the bacterial strains tested (MIC values between 12.5 mug/ml and 400 mug/ml, and MBC values between 25 mug/ml and 400 mug/ml). In addition, sub-MIC levels of the Crude extracts and their hexane fractions significantly inhibited the adherence of the microorganisms to a glass surface. The data indicate that the biologically active compounds are present mostly in the hexane fraction of both Mikania species, which showed remarkable inhibitory activities against mutans streptococci. Mikania genus plant is a promising Source for novel antimicrobial agents against oral pathogens. (C) 2004 Published by Elsevier Ireland Ltd.|
|Editor:||Elsevier Sci Ireland Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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