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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffects of melatonin administration to rats with glycerol-induced acute renal failurept_BR
dc.contributor.authorFerraz, FFpt_BR
dc.contributor.authorKos, AGpt_BR
dc.contributor.authorJanino, Ppt_BR
dc.contributor.authorHomsi, Ept_BR
unicamp.authorUniv Estadual Campinas, Fac Ciencias Med, Div Nephrol, Sao Paulo, Brazilpt_BR
dc.subjectglycerol-induced acute renal failurept_BR
dc.subjectmelatoninpt_BR
dc.subjectlipid peroxidationpt_BR
dc.subjectreduced glutathionept_BR
dc.subject.wosOxidative Stresspt_BR
dc.subject.wosAntioxidant Propertiespt_BR
dc.subject.wosGlutathionept_BR
dc.subject.wosInjurypt_BR
dc.subject.wosRhabdomyolysispt_BR
dc.subject.wosAdriamycinpt_BR
dc.subject.wosInhibitionpt_BR
dc.subject.wosMyoglobinpt_BR
dc.subject.wosReductionpt_BR
dc.subject.wosProteinpt_BR
dc.description.abstractMelatonin, the pineal hormone with antioxidative properties was administered to rats with glycerol-induced myoglobinuric acute renal failure (Gly-ARF). This model is characterized by acute tubular necrosis mediated by heme-iron oxidative stress. Rats received melatonin (20 mg/kg) concomitant and 3 h after glycerol injection. Gly-ARF rats showed at 24 h a 78% reduction in glomerular filtration rate, whereas this decrement was significantly reduced to 35% in the melatonin treated Gly-ARF rats. Tubular function evaluated by tubular reabsorption of sodium and lithium was also preserved in melatonin treated rats. The histologic analysis revealed extensive cortical tubular necrosis that was significantly reduced by melatonin treatment. The renal concentration of malondialdehyde (MDA) was increased 6 h after glycerol injection in Gly-ARF and this elevation was prevented when melatonin was administered. Renal concentration of reduced glutathione (GSH)-was decreased at 6 h in Gly-ARF and melatonin did not reverse this decrease. It was concluded that melatonin administration attenuated the renal injury in the glycerol model of acute renal failure and reduced kidney oxidative stress through a GSH-independent mechanism.pt
dc.relation.ispartofRenal Failurept_BR
dc.relation.ispartofabbreviationRen. Fail.pt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherMarcel Dekker Incpt_BR
dc.date.issued2002pt_BR
dc.identifier.citationRenal Failure. Marcel Dekker Inc, v. 24, n. 6, n. 735, n. 746, 2002.pt_BR
dc.language.isoenpt_BR
dc.description.volume24pt_BR
dc.description.issuenumber6pt_BR
dc.description.initialpage735pt_BR
dc.description.lastpage746pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0886-022Xpt_BR
dc.identifier.wosidWOS:000179650400005pt_BR
dc.identifier.doi10.1081/JDI-120015677pt_BR
dc.date.available2014-11-17T21:06:51Z
dc.date.available2015-11-26T16:46:38Z-
dc.date.accessioned2014-11-17T21:06:51Z
dc.date.accessioned2015-11-26T16:46:38Z-
dc.description.provenanceMade available in DSpace on 2014-11-17T21:06:51Z (GMT). No. of bitstreams: 1 WOS000179650400005.pdf: 167975 bytes, checksum: d8eac327017d9d53f26c9e1674d4c7c7 (MD5) Previous issue date: 2002en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:46:38Z (GMT). No. of bitstreams: 2 WOS000179650400005.pdf: 167975 bytes, checksum: d8eac327017d9d53f26c9e1674d4c7c7 (MD5) WOS000179650400005.pdf.txt: 28726 bytes, checksum: 90e8796c82514925cdc4839d5640a453 (MD5) Previous issue date: 2002en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65012pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/65012
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65012-
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