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Type: Artigo de periódico
Title: Effects of maternal ethanol intake on immunoexpression of epidermal growth factor in developing rat mandibular molar
Author: Sant'Anna, LB
Tosello, DO
Pasetto, S
Abstract: Objective: A polyclonal antibody was used to investigate the effects of ethanol ingestion before and during pregnancy, in the expression of EGF on dentinogenesis and amelogenesis of rat mandibular first molar. Design: Ethanol was administered to drinking water (treated group) starting at concentrations of 1% and increasing weekly to 5, 10, 15, 20 and 25% (v/v). During week 7, these rats were mated and continued to receive the 25% alcoholic solution, up to delivery. The control group received tap water. On postnatal days 0, 4 and 9, two offspring of each titter were killed, their hemimandibles removed and prepared for paraffin processing and immunohistochemistry. Results: At postnatal day 0 the EGF immunoreactivity of the inner enamel epithelium and presecretory amelobtasts was weak when compared to controls. At postnatal day 4 EGF immunoreactivity of the secretory ameloblasts and odontoblasts was only moderate compared to controls. At postnatal day 9 EGF staining of the ameloblasts was weak when compared to controls. Conclusions: These results suggest that, maternal alcoholism interferes with EGF expression during initial dentinogenesis and amelogenesis and in the secretion and maturation of the dentin and enamel, therefore, which may cause a reduction of dentin and enamel formation. (c) 2005 Elsevier Ltd. All rights reserved.
Subject: amelogenesis
epidermal growth factor
ethanol immunohistochemistry
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Archives Of Oral Biology. Pergamon-elsevier Science Ltd, v. 50, n. 7, n. 625, n. 634, 2005.
Rights: fechado
Identifier DOI: 10.1016/j.archoralbio.2004.12.010
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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