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Type: Artigo de periódico
Title: Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
Author: Toyama, MH
Toyama, DO
Torres, VM
Pontes, GC
Farias, WRL
Melo, FR
Oliveira, SCB
Fagundes, FHR
Diz, EBS
Cavada, BS
Abstract: Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
Subject: Botryocladia occidentalis
Crotalus durissus cascavella
Secretory phospholipase A2 (sPLA2)
Country: EUA
Editor: Springer
Citation: Protein Journal. Springer, v. 29, n. 8, n. 567, n. 571, 2010.
Rights: fechado
Identifier DOI: 10.1007/s10930-010-9294-9
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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