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Type: Artigo de periódico
Title: Effects of Lercanidipine on Bone Density and Bone Repair in Spontaneously Hypertensive Rats
Author: Bastos, MF
de Araujo, IV
Brilhante, FV
Pires, AG
Goncalves, TED
Napimoga, MH
Marques, MR
Duarte, PM
Abstract: Purpose: To evaluate the effects of the lercanidipine on bone healing (BH) and bone density (BD) in the tibiae of spontaneously hypertensive rats (SHR), using histometric and tartrate-resistant acid phosphatase (TRAP) expression analyses. Materials and Methods: Wistar and SHR were assigned to one of the following groups: normotensive rats (NTR) (n = 15), untreated SHR (n = 15), and lercanidipine-treated SHR (n = 15). The latter group was treated daily with lercanidipine for 6 weeks. Two weeks after the beginning of drug administration, a critical-sized surgical defect was created in the right tibia of all groups, whereas the contralateral tibia remained without defect. The animals were killed 30 days after the creation of the bone defect. Results: There were no significant differences among the groups for BH, trabecular BD, and the number of TRAP+ cells in the newly formed cortical bone (P > 0.05). SHR presented significantly lower cortical BD and increased cortical levels of TRAP+ cells, when compared with NTR and lercanidipine-treated SHR (P < 0.05). Conclusion: SHR presented a lower cortical BD and increased levels of TRAP+ cells. In addition, the treatment of SHR with lercanidipine during 6 weeks was able to revert the deleterious effects of hypertension on cortical BD and on the number of TRAP+ cells in the tibia of SHR. (Implant Dent 2013;22:49-54)
Subject: lercanidipine
bone density
spontaneously hypertensive rats
TRAP protein
Country: EUA
Editor: Lippincott Williams & Wilkins
Citation: Implant Dentistry. Lippincott Williams & Wilkins, v. 22, n. 1, n. 49, n. 54, 2013.
Rights: fechado
Identifier DOI: 10.1097/ID.0b013e3182777650
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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