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Type: Artigo de periódico
Title: Endothelin ETA receptor antagonism attenuates the presser effects of nicotine in rats
Author: Tanus-Santos, JE
Sampaio, RC
Hyslop, S
Franchini, KG
Moreno, H
Abstract: The increased endotheIin-1 levels observed after smoking may result from nicotine-stimulated endothelin-1 production by endothelial cells. In this study, we investigated the effects of selective endothelin ETA receptors antagonist Cycle D-a-aspartyl-L-prolyl-D-isoleucyl-D-tryptophyl (JKC 301) and of endothelin ETB receptors antagonist N-cis-2,6-dimethylpiperidino-carbonyl-L-gamma-methyl-leucyl-D-L-methoxycarbonyl-tryptophanyl-norleucine (BQ 788) on the changes in mean arterial pressure, heart rate, and plasma thromboxane B-2 (the stable product of thromboxane A(2)) levels caused by increasing doses of nicotine (0.6, 2, 6, and 20 mu mol/kg) in anesthetised rats. Nicotine (0.6, 2, and 6 mu mol/kg) significantly increased the mean arterial pressure in control and BQ 788-pretreated rats, while only a nicotine dose of 2 mu mol/kg) increased the mean arterial pressure in JKC 301-pretreated animals. There were no differences in the nicotine-induced changes in heart rate or in the increases in thromboxane B-2 levels among the groups treated with saline, JKC 301 and BQ 788. These results demonstrate that whereas the antagonism of-endothelin ETA receptors attenuated the increase in blood pressure after nicotine injections, endothelin ETB receptor antagonism had no such effect. In addition, the antagonism of endothelin ETA or ETB receptors did not affect thromboxane A(2) production after nicotine administration. These findings suggest that endothelin-1 may have a role in the acute effects of nicotine. (C) 2000 Elsevier Science B.V. All rights reserved.
Subject: blood pressure
endothelin receptor antagonist
Country: Holanda
Editor: Elsevier Science Bv
Citation: European Journal Of Pharmacology. Elsevier Science Bv, v. 396, n. 1, n. 33, n. 37, 2000.
Rights: fechado
Identifier DOI: 10.1016/S0014-2999(00)00194-1
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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