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Type: Artigo de periódico
Title: Endoscopic study of the intranasal ostium in external dacryocystorhinostomy postoperative. Influence of saline solution and 5-fluorouracil
Author: Costa, MN
Marcondes, AM
Sakano, E
Kara-Jose, N
Abstract: PURPOSE: To study, through endoscopy, the postoperative structural changes of the intranasal ostium following external dacryocystorhinostomy and to evaluate the influence of saline solution and 5-fluorouracil. METHODS: Fifty patients were distributed into the following groups: Group SS-dacryocystorhinostomy and an injection of saline solution during surgery (13 patients); Group 5-FUI-dacryocystorhinostomy and an injection of 5 fluorouracil during surgery (17 patients); Group C-dacryocystorhinostomy only (11 patients); Group 5-FU3-dacryocystorhinostomy and 3 injections, 1 during surgery and 1 on the third and fifth postsurgical days (9 patients). RESULTS: Pair-wise group comparisons using the nonparametric Mann-Whitney test revealed that there was a significant reduction of the ostium area only in Group 5-FU1 vs. Group SS on the 60(th) postoperative day (P < .01); however, a comparative study among the 4 groups using the Kruskal-Wallis test showed no significant changes in the ostium area on the 60(th) postoperative day. The ostium area within groups at the 30(th) vs 60(th) postoperative day was significantly reduced for Group C (P < .05; Mann-Whitney test); no significant changes were found for the other groups. DISCUSSION: These results suggest that the use of 5-fluorouracil in external dacryocystorhinostomy does not significantly influence the final size of the surgical fistula as determined 2 months postsurgery.
Subject: fluorouracil
Country: Brasil
Editor: Hospital Clinicas, Univ Sao Paulo
Citation: Clinics. Hospital Clinicas, Univ Sao Paulo, v. 62, n. 1, n. 41, n. 46, 2007.
Rights: aberto
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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