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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEndometrial histology, microvascular density and caliber, and matrix metalloproteinase-3 in users of the Nestorone (R)-releasing contraceptive implant with and without endometrial breakthrough bleedingpt_BR
dc.contributor.authorOliveira-Ribeiro, Mpt_BR
dc.contributor.authorPetta, CApt_BR
dc.contributor.authorAndrade, LALDApt_BR
dc.contributor.authorHidalgo, MMpt_BR
dc.contributor.authorPellogia, Apt_BR
dc.contributor.authorBahamondes, Lpt_BR
unicamp.author.emailcpetta@attglobal.netpt_BR
unicamp.authorUniv Estadual Campinas, Sch Med, Human Reprod Unit, Dept Obstet & Gynecol, BR-13084971 Campinas, SP, Brazil Univ Estadual Campinas, Sch Med, Dept Pathol, BR-13084971 Campinas, SP, Brazilpt_BR
dc.subjectendometrial bleedingpt_BR
dc.subjectsubdermal progestin implantpt_BR
dc.subjectNestoronept_BR
dc.subjectleukocytespt_BR
dc.subjectMMP-3/microvesselspt_BR
dc.subject.wosIntrauterine Levonorgestrel Deliverypt_BR
dc.subject.wosProgestin-only Contraceptivespt_BR
dc.subject.wosSerum Steroid Concentrationspt_BR
dc.subject.wosOvarian-functionpt_BR
dc.subject.wosMenstrual-cyclept_BR
dc.subject.wosInterstitial Collagenasept_BR
dc.subject.wosVaginal Ringspt_BR
dc.subject.wosGelatinase-bpt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosSt-1435pt_BR
dc.description.abstractObjective: This descriptive study evaluated endometrial histology, microvascular density and caliber, and quantification of matrix metalloproteinase (MMP-3) expression in long-term users of the Nestorone (R) (NES)-releasing implant who presented or not endometrial breakthrough bleeding (BTB). Methods: Endometrial biopsies were obtained from 32 healthy women with unpredictable BTB. The quantitative analysis was performed only in 20 samples. Results: The mean duration of use of the implant among the 14 women with BTB was 19.6 +/- 1.0 months, and the other six women had used the implant for 17.7 +/- 2.3 months (mean +/- S.E.M.). Histological analysis of the endometrial tissue showed a predominance of progestogenic pattern followed by atrophic and proliferative endometrium in both groups. Mucosal breakdown and glandular pseudostratification were observed in half of the cases. Endometrial vascular density was 73.1 +/- 10.0 and 57.5 +/- 24.1 vessels/mm(2), and maximum vessel diameter was 923.3 +/- 86.0 and 1038.0 +/- 404 mu m (mean S.E.M.) in the group with and without BTB, respectively, without significance, and the rate of cells expressing MMP-3 x 1000 counted stromal cells was 155.8 +/- 24.8 and 127.0 +/- 19.0 (mean +/- S.E.M.) in both groups, respectively, without significance. Conclusions: This study provides information about some endometrial aspects of women using NES in contraceptive implants. In addition, the endometrium was similar during long-tern use of NES-releasing contraceptive implants in women with and without endometrial bleeding. (c) 2006 Elsevier Inc. All rights reserved.pt
dc.relation.ispartofContraceptionpt_BR
dc.relation.ispartofabbreviationContraceptionpt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherElsevier Science Incpt_BR
dc.date.issued2006pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationContraception. Elsevier Science Inc, v. 73, n. 6, n. 634, n. 640, 2006.pt_BR
dc.language.isoenpt_BR
dc.description.volume73pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage634pt_BR
dc.description.lastpage640pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0010-7824pt_BR
dc.identifier.wosidWOS:000238206500017pt_BR
dc.identifier.doi10.1016/j.contraception.2005.10.013pt_BR
dc.date.available2014-11-20T07:20:31Z
dc.date.available2015-11-26T16:08:42Z-
dc.date.accessioned2014-11-20T07:20:31Z
dc.date.accessioned2015-11-26T16:08:42Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:08:42Z (GMT). No. of bitstreams: 2 WOS000238206500017.pdf: 205571 bytes, checksum: 22124bdadba72dc4844aa187fce59075 (MD5) WOS000238206500017.pdf.txt: 37373 bytes, checksum: d55fe6d1a66b0f57ead9ef2a5457f72c (MD5) Previous issue date: 2006en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64752pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/64752
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64752-
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