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Type: Artigo de periódico
Title: Endometrial histology, microvascular density and caliber, and matrix metalloproteinase-3 in users of the Nestorone (R)-releasing contraceptive implant with and without endometrial breakthrough bleeding
Author: Oliveira-Ribeiro, M
Petta, CA
Andrade, LALDA
Hidalgo, MM
Pellogia, A
Bahamondes, L
Abstract: Objective: This descriptive study evaluated endometrial histology, microvascular density and caliber, and quantification of matrix metalloproteinase (MMP-3) expression in long-term users of the Nestorone (R) (NES)-releasing implant who presented or not endometrial breakthrough bleeding (BTB). Methods: Endometrial biopsies were obtained from 32 healthy women with unpredictable BTB. The quantitative analysis was performed only in 20 samples. Results: The mean duration of use of the implant among the 14 women with BTB was 19.6 +/- 1.0 months, and the other six women had used the implant for 17.7 +/- 2.3 months (mean +/- S.E.M.). Histological analysis of the endometrial tissue showed a predominance of progestogenic pattern followed by atrophic and proliferative endometrium in both groups. Mucosal breakdown and glandular pseudostratification were observed in half of the cases. Endometrial vascular density was 73.1 +/- 10.0 and 57.5 +/- 24.1 vessels/mm(2), and maximum vessel diameter was 923.3 +/- 86.0 and 1038.0 +/- 404 mu m (mean S.E.M.) in the group with and without BTB, respectively, without significance, and the rate of cells expressing MMP-3 x 1000 counted stromal cells was 155.8 +/- 24.8 and 127.0 +/- 19.0 (mean +/- S.E.M.) in both groups, respectively, without significance. Conclusions: This study provides information about some endometrial aspects of women using NES in contraceptive implants. In addition, the endometrium was similar during long-tern use of NES-releasing contraceptive implants in women with and without endometrial bleeding. (c) 2006 Elsevier Inc. All rights reserved.
Subject: endometrial bleeding
subdermal progestin implant
Country: EUA
Editor: Elsevier Science Inc
Citation: Contraception. Elsevier Science Inc, v. 73, n. 6, n. 634, n. 640, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.contraception.2005.10.013
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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