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Type: Artigo de periódico
Title: Enantioselective synthesis of 2-ethyl-2,3-dihydrobenzofuran carboxylic acid, direct precursor of (+)-efaroxan, from a Baylis-Hillman adduct
Author: Silveira, GPD
Coelho, F
Abstract: We describe herein a new and straightforward enantioselective approach to R-(+)-2-ethyl-2,3-dihydrofuran carboxylic acid, the direct precursor of (+)-efaroxan, an alpha(2) adrenoreceptor antagonist, which is indicated to be used for the treatment of neuro-degenerative diseases (Alzheimer and Parkinson), migraine and type Iota Iota diabetes. Our goal was accomplished using a Baylis-Hillman adduct as starting material. The dihydrobenzofuran acid was obtained in eight steps with an overall yield of 14%. (c) 2005 Elsevier Ltd. All rights reserved.
Subject: Baylis-Hillman
asymmetric synthesis
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 46, n. 38, n. 6477, n. 6481, 2005.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2005.07.099
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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