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Type: Artigo de periódico
Title: Enantioselective bioreduction of (E)-1-phenyl-1,2-alkanedione 2-(O-methyloxime)
Author: Kreutz, OC
Segura, RCM
Rodrigues, JAR
Moran, PJS
Abstract: The baker's yeast reduction of (E)-1-phenyI-1,2-alkanedione 2-(O-methyloxime), PhC(O)C(NOMe)R (R = Me, Et, n-Pr, n-Bu), gave the corresponding optically active alcohols PhCH2OHC(NOMe)R in 88-99% enantiomeric excess and 48-75% chemical yield. The R configuration was proposed for these alcohols based on circular dichroism analysis. Only the phenylglyoxal O-methylaldoxime (R=H) gave poor enantiomeric excess (65%) and chemical yield (14%). These compounds are potential chiral building blocks for the stereoselective synthesis of norephedrine analogs. (C) 2000 Elsevier Science Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron-asymmetry. Pergamon-elsevier Science Ltd, v. 11, n. 10, n. 2107, n. 2115, 2000.
Rights: fechado
Identifier DOI: 10.1016/S0957-4166(00)00163-4
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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