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Type: Artigo de periódico
Title: Enantioselective benzylic microbial hydroxylation of indan and tetralin
Author: Limberger, RP
Ursini, CV
Moran, PJS
Rodrigues, JAR
Abstract: A screening with 15 strains of bacteria and fungi targeted at the production of specific hydroxylated benzylic derivatives of indan 1 and tetralin 2 was carried out. Mortierella isabellina, Mortierella ramanniana and Beauveria bassiana were shown to mediate the respective conversions to 1-indanol (3) and 1-tetralol (4), the most satisfactory results being obtained with M. isabellina, which gave 78% conversion of I to (1R)-3 (64% yield, 86% ee) after a 2-day-incubation, and 52% conversion of 2 to (IR)-4 (38% yield, 92% ee) in a 4-day-incubation. Over-oxidation of alcohols 3 and 4 during the reactions resulted on the formation of 1-indanone and 2-tetralone, respectively. (c) 2007 Elsevier B.V. All rights reserved.
Subject: Mortierella
Country: Holanda
Editor: Elsevier Science Bv
Citation: Journal Of Molecular Catalysis B-enzymatic. Elsevier Science Bv, v. 46, n. 41730, n. 37, n. 42, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.molcatb.2007.02.003
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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