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Type: Artigo de periódico
Title: Enantiodivergence in the reduction of alpha-methyl and alpha-halomethyl enones by microorganisms
Author: de Paula, BRS
Zampieri, DS
Rodrigues, JAR
Moran, PJS
Abstract: Enones (Z)-3-methyl-(Z)-3-chloromethyl- and (Z)-3-bromomethyl-4-R-3-buten-2-one (R = n-pentyl, phenyl, 2'- and 4'-chlorophenyl, 3'- and 4'-nitrophenyl, 4'-methoxyphenyl) were synthesized and subjected to reduction by the microorganisms Saccharomyces cerevisiae and Geotrichum candidum. Whereas the bioreduction of 3-methy-4-R-3-buten-2-ones afforded the corresponding (S)-4-R-3-methybutan-2-ones, the bioreduction of 3-chloromethyl- and 3-bromomethyl-4-R-3-buten-2-ones afforded the corresponding (R)-4-R-3-methybutan-2-ones. (C) 2013 Elsevier Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron-asymmetry. Pergamon-elsevier Science Ltd, v. 24, n. 17, n. 973, n. 981, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.tetasy.2013.07.007
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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