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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleENALAPRIL REDUCES THE ALBUMINURIA OF PATIENTS WITH SICKLE-CELL DISEASEpt_BR
dc.contributor.authorAOKI, RYpt_BR
dc.contributor.authorSAAD, STOpt_BR
unicamp.authorUNICAMP,HEMOCTR,BR-13081970 CAMPINAS,SP,BRAZIL UNICAMP,DEPT INTERNAL MED,DIV HEMATOL,BR-13081970 CAMPINAS,SP,BRAZILpt_BR
dc.subject.wosAngiotensin-converting Enzymept_BR
dc.subject.wosDiabetic Nephropathypt_BR
dc.subject.wosRenal Hemodynamicspt_BR
dc.subject.wosLithium Clearancept_BR
dc.subject.wosHypertensionpt_BR
dc.subject.wosProteinuriapt_BR
dc.subject.wosMicroalbuminuriapt_BR
dc.subject.wosInhibitionpt_BR
dc.subject.wosCaptoprilpt_BR
dc.subject.wosAnemiapt_BR
dc.description.abstractPURPOSE: TO evaluate the effects of enalapril, an angiotensin-converting enzyme inhibitor, on albuminuria associated with sickle cell anemia. PATIENTS AND METHODS: TWO males and 6 females, mean age 22.8 +/- 5.5 years, with sickle cell anemia and albuminuria, received enalapril for 6 months. Before entry into the study, all had a urinary albumin concentration above 30 mg/L as determined by radioimmunoassay documented on three separate occasions at intervals of 15 to 30 days. Samples were collected before 10 AM after an oral water load of 10 mL/kg. RESULTS: Enalapril reduced 6 patients' pretreatment hyperalbuminuria to normal. One patient whose levels did not reach normal values experienced a reduction of 70%. Fractional excretion of sodium, potassium, and lithium did not change during the treatment. Mean arterial pressure decreased by 8.6 +/- 0.42 mm Hg. Two years after enalapril was discontinued, there were no changes in sodium, potassium, or creatinine levels of 7 patients who had received enalapril or in their mean arterial pressures. Urinary albumin concentration increased relative to pretreatment levels in 2 individuals, returned to pretreatment levels in 2, and remained below 30 mg/L in 2. CONCLUSION: Our results demonstrate that enalapril reduces albuminuria in patients with sickle cell anemia. After discontinuation of the drug, however, the albuminuria may increase to pretreatment levels or higher. Whether the reduction in urinary albumin concentration by angiotensin-converting enzyme inhibitors can delay the development of progressive renal failure in sickle cell anemia patients remains to be established.pt
dc.relation.ispartofAmerican Journal Of Medicinept_BR
dc.relation.ispartofabbreviationAm. J. Med.pt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisherCahners Publ Copt_BR
dc.date.issued1995pt_BR
dc.date.monthofcirculationMAYpt_BR
dc.identifier.citationAmerican Journal Of Medicine. Cahners Publ Co, v. 98, n. 5, n. 432, n. 435, 1995.pt_BR
dc.language.isoenpt_BR
dc.description.volume98pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage432pt_BR
dc.description.lastpage435pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0002-9343pt_BR
dc.identifier.wosidWOS:A1995QW86400003pt_BR
dc.identifier.doi10.1016/S0002-9343(99)80341-6pt_BR
dc.date.available2014-12-16T11:37:32Z
dc.date.available2015-11-26T16:26:33Z-
dc.date.accessioned2014-12-16T11:37:32Z
dc.date.accessioned2015-11-26T16:26:33Z-
dc.description.provenanceMade available in DSpace on 2014-12-16T11:37:32Z (GMT). No. of bitstreams: 1 WOSA1995QW86400003.pdf: 520781 bytes, checksum: a1aa72eae2b5de188a08c5ae9a957476 (MD5) Previous issue date: 1995en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:26:33Z (GMT). No. of bitstreams: 2 WOSA1995QW86400003.pdf: 520781 bytes, checksum: a1aa72eae2b5de188a08c5ae9a957476 (MD5) WOSA1995QW86400003.pdf.txt: 18797 bytes, checksum: 098e62f78539356547852405421996d7 (MD5) Previous issue date: 1995en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64712pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/64712
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64712-
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