Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/64654
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleElevated Plasma Hemoglobin Levels Increase Nitric Oxide Consumption in Experimental and Clinical Acute Pulmonary Thromboembolismpt_BR
dc.contributor.authorSertorio, JTpt_BR
dc.contributor.authorNeto-Neves, EMpt_BR
dc.contributor.authorDias-Junior, CApt_BR
dc.contributor.authorSousa-Santos, Opt_BR
dc.contributor.authorKiss, Tpt_BR
dc.contributor.authorMuhl, Dpt_BR
dc.contributor.authorTanus-Santos, JEpt_BR
unicamp.author.emailtanus@fmrp.usp.brpt_BR
unicamp.authorSertorio, Jonas T. Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazilpt_BR
unicamp.authorNeto-Neves, Evandro M. Sousa-Santos, Ozelia Tanus-Santos, Jose E. Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazilpt_BR
unicamp.authorDias-Junior, Carlos A. State Univ Sao Paulo, Dept Pharmacol, Botucatu, SP, Brazilpt_BR
unicamp.authorKiss, Tamas Muehl, Diana Univ Pecs, Dept Anaesthesia & Intens Care, Pecs, Hungarypt_BR
dc.subjectacute pulmonary thromboembolismpt_BR
dc.subjectconsumptionpt_BR
dc.subjecthemoglobinpt_BR
dc.subjecthemolysispt_BR
dc.subjectnitric oxidept_BR
dc.subjectpulmonary embolismpt_BR
dc.subjectpulmonary hypertensionpt_BR
dc.subject.wosCell-free Hemoglobinpt_BR
dc.subject.wosStorage Lesionpt_BR
dc.subject.wosHemodynamic Instabilitypt_BR
dc.subject.wosSildenafil Improvespt_BR
dc.subject.wosCanine Modelpt_BR
dc.subject.wosL-argininept_BR
dc.subject.wosEmbolismpt_BR
dc.subject.wosHemolysispt_BR
dc.subject.wosHypertensionpt_BR
dc.subject.wosDiseasept_BR
dc.description.abstractObjectives: We examined whether experimental lung embolization with autologous blood clots or with the infusion of microspheres increase cell-free hemoglobin levels and nitric oxide consumption by plasma samples from anesthetized lambs. These parameters were also measured in patients with acute pulmonary thromboembolism at baseline conditions and after thrombolysis, and in healthy controls. Design: Controlled animal and clinical studies. Setting: University research laboratory and university hospital. Subjects: Sheep and humans. Interventions: Anesthetized lambs were embolized with intravenous injections of autologous blood clots or repeated injections of 300 m microspheres. Control animals received saline. Blood samples were drawn from patients with acute pulmonary thromboembolism at baseline conditions and after thrombolytic therapy with streptokinase or alteplase. Measurements and Main Results: Hemodynamic measurements were performed and plasma cell-free hemoglobin concentrations were measured. A nitric oxide consumption assay was used to measure nitric oxide consumption by plasma samples. Embolization with blood clots or microspheres increased mean pulmonary artery pressure from similar to 15 to similar to 40 mm Hg in lambs. Both plasma hemoglobin concentrations and nitric oxide consumption increased in proportion to the hemodynamic alterations and correlated significantly. Patients with acute pulmonary thromboembolism had higher plasma hemoglobin concentrations and nitric oxide consumption than healthy controls. Thrombolysis with streptokinase or alteplase further increased both parameters, which peaked 1-3 days after thrombolysis. Conclusions: Our results show consistent evidence indicating a new mechanism involving increased hemoglobin decompartmentalization and augmented nitric oxide consumption, possibly contributing to the hemodynamic derangement of acute pulmonary thromboembolism.pt
dc.relation.ispartofCritical Care Medicinept_BR
dc.relation.ispartofabbreviationCrit. Care Med.pt_BR
dc.publisher.cityPhiladelphiapt_BR
dc.publisher.countryEUApt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationCritical Care Medicine. Lippincott Williams & Wilkins, v. 41, n. 7, n. E118, n. E124, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume41pt_BR
dc.description.issuenumber7pt_BR
dc.description.firstpageE118pt_BR
dc.description.lastpageE124pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESP USPpt_BR
dc.identifier.issn0090-3493pt_BR
dc.identifier.wosidWOS:000320579800002pt_BR
dc.identifier.doi10.1097/CCM.0b013e31827c0b43pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-07-30T17:19:20Z
dc.date.available2015-11-26T17:46:33Z-
dc.date.accessioned2014-07-30T17:19:20Z
dc.date.accessioned2015-11-26T17:46:33Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T17:19:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:46:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64654
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64654-
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