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Type: Artigo de periódico
Title: Electrospray ionization mass and tandem mass spectra of a series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines: new dopaminergic ligands with potential antipsychotic properties
Author: Santos, LS
Padilha, MC
Neto, FRD
Pereira, AD
Menegatti, R
Fraga, CAM
Barreiro, EJ
Eberlin, MN
Abstract: Recently, two analogous series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines have been prepared and found to be potential antipsychotic drugs acting as new selective ligands of the dopamine D2 receptor. Herein we report a systematic study of their high-resolution electrospray ionization mass and tandem mass spectra in which the main dissociation routes of their protonated molecules are determined and rationalized. The ESI-MS/MS data is very characteristic for both series allowing straightforward isomeric differentiation. A single and dominant fragment ion for the pyrazole series and four major fragment ions for the triazole series are useful for selective reaction MS monitoring of these potential drugs in biological fluids. Copyright (c) 2005 John Wiley & Sons, Ltd.
Subject: tandem mass spectrometry
antipsychotic drugs
dopamine receptor ligands
ion chemistry
Country: Inglaterra
Editor: John Wiley & Sons Ltd
Citation: Journal Of Mass Spectrometry. John Wiley & Sons Ltd, v. 40, n. 6, n. 815, n. 820, 2005.
Rights: fechado
Identifier DOI: 10.1002/jms.857
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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