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Type: Artigo de periódico
Title: Effect of Low-Level Laser Therapy in the Myonecrosis Induced by Bothrops jararacussu Snake Venom
Author: Barbosa, AM
Villaverde, AB
Sousa, LG
Munin, E
Fernandez, CM
Cogo, JC
Zamuner, SR
Abstract: Objective: The aim of this work was to investigate the capacity of low-level laser therapy (LLLT) alone or in combination with antivenom (AV) to reduce myonecrosis induced by Bothrops jararacussu snake venom. Background Data: Myonecrosis is the most pronounced local effect caused by B. jararacussu venom. AV therapy and other first-aid treatments do not reverse these local effects. Material and Methods: Male Swiss mice were used. Myonecrosis was induced by injection of 0.6mg/kg of B. jararacussu venom in the right gastrocnemius muscle and was evaluated at 3 or 24 h after venom injection. The site of venom administration was irradiated for 29s with a low power semiconductor laser (685 nm) at a dose of 4.2 J/cm(2). Intravenous AV therapy (0.5 mL dose) was administered at different times: 30 min before venom injection or 0, 1, or 3 h afterward. Both AV therapy and LLLT treatments were duplicated in mice groups killed at 3 or 24 h. Results: B. jararacussu venom caused a significant myonecrotic effect 3 and 24 h after venom injection. LLLT significantly reduced myonecrosis by 83.5% at 24h (p < 0.05) but not at 3 h, and AV therapy alone was ineffective for reducing myonecrosis at 3 and 24 h. Conclusion: Only LLLT significantly reduced myonecrosis of the envenomed muscle, suggesting that LLLT is a potentially therapeutic approach for treating the local effects of B. jararacussu venom.
Country: EUA
Editor: Mary Ann Liebert Inc
Citation: Photomedicine And Laser Surgery. Mary Ann Liebert Inc, v. 27, n. 4, n. 591, n. 597, 2009.
Rights: embargo
Identifier DOI: 10.1089/pho.2008.2296
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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