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Type: Artigo de periódico
Title: Effect of intraperitioneally administered hydrolyzed whey protein on blood pressure and renal sodium handling in awake spontaneously hypertensive rats
Author: Costa, EL
Almeida, AR
Netto, FM
Gontijo, JAR
Abstract: The present study evaluated the acute effect of the intraperitoneal. (ip) administration of a whey protein hydrolysate (WPH) on systolic arterial blood pressure (SBP) and renal sodium handling by conscious spontaneously hypertensive rats (SHR). The ip administration of WPH in a volume of 1 ml dose-dependently lowered the SBP in SHR 2 h after administration at doses of 0.5 g/kg (0.15 M NaCl: 188.5 +/- 9.3 mmHg vs WPH: 176.6 +/- 4.9 mmHg, N = 8, P = 0.001) and 1.0 g/kg (0.15 M NaCl: 188.5 9.3 mmHg vs WPH: 163.8 +/- 5.9 mmHg, N = 8, P = 0.0018). Creatinine clearance decreased significantly (P = 0.0084) in the WPH-treated group (326 +/- 67 mu L min(-1) 100 g body weight(-1)) compared to 0.15 M NaCl-treated (890 26 mu L min(-1) 100 g body weight(-1)) and captopril-treated (903 +/- 72 mu L min(-1) 100 g body weight(-1)) rats. The ip administration of 1.0 g WPH/kg also decreased fractional sodium excretion to 0.021 +/- 0.019% compared to 0.126 +/- 0.041 and 0.66 +/- 0.015% in 0.15 M NaCl and captopril-treated rats, respectively (P = 0.033). Similarly, the fractional potassium excretion in WPH-treated rats (0.25 +/- 0.05%) was significantly lower (P = 0.0063) than in control (0.91 +/- 0.15%) and captopril-treated rats (1.24 +/- 0.30%), respectively. The present study shows a decreased SBP in SHR after the administration of WPH associated with a rise in tubule sodium reabsorption despite an angiotensin I-converting enzyme (ACE)-inhibiting in vitro activity (IC50 = 0.68 mg/mL). The present findings suggest a pathway involving ACE inhibition but measurements of plasma ACE activity and angiotensin Id levels are needed to support this suggestion.
Subject: arterial blood pressure
renal function
urinary sodium excretion
whey protein isolate
Country: Brasil
Editor: Assoc Bras Divulg Cientifica
Citation: Brazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 38, n. 12, n. 1817, n. 1824, 2005.
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2005001200010
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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