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Type: Artigo de periódico
Title: Effect of mucosal fluid from women with bacterial vaginosis on HIV trans-infection mediated by dendritic cells
Author: St John, EP
Zariffard, MR
Martinson, JA
Simoes, JA
Landay, AL
Spear, GT
Abstract: Women with bacterial vaginosis (BV) have a higher risk of HIV transmission but the cause of risk is unknown. Dendritic cells (DC) are implicated in transmission of HIV and we previously observed that DC mature when exposed to mucosal fluid from women with BV. We hypothesized that maturation of DC by BV mucosal fluid would enhance DC-mediated trans-infection of HIV. Monocyte-derived DC (MDDC) were treated with mucosal fluid, incubated with HIV(Bal), and HIV trans-infection was evaluated. While LPS-treated MDDC increased HIV(Bal) trans-infection, BV fluid reduced trans-infection. HIV(Bal) DNA levels in MDDC were not affected by BV fluid or LPS but productive infection of MDDC was decreased by LPS and BV fluid. Mucosal fluid from women with BV does not increase MDDC-mediated trans-infection suggesting that BV does not increase HIV susceptibility by increasing DC-mediated trans-infection. However, indirect effects of DC maturation on HIV transmission cannot be ruled out. (c) 2008 Elsevier Inc. All rights reserved.
Subject: HIV
Bacterial vaginosis
Dendritic cells
Cervical vaginal lavage
Toll-like receptors
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Virology. Academic Press Inc Elsevier Science, v. 385, n. 1, n. 22, n. 27, 2009.
Rights: fechado
Identifier DOI: 10.1016/j.virol.2008.08.031
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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