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Type: Artigo de periódico
Title: Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation
Author: Hollanda, LM
Cury, GCG
Pereira, RFC
Ferreira, GA
Sousa, A
Sousa, EMB
Lancellotti, M
Abstract: Background: This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement. Methods: we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency. Results: we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles. Conclusion: the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis.
Country: Inglaterra
Editor: Biomed Central Ltd
Citation: Journal Of Nanobiotechnology. Biomed Central Ltd, v. 9, 2011.
Rights: aberto
Identifier DOI: 10.1186/1477-3155-9-28
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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