Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/64244
Type: Artigo de periódico
Title: EFFECT OF PROPRANOLOL AND NIFEDIPINE ON INVITRO FLUID ABSORPTION BY THE ISOLATED PERFUSED PROXIMAL CONVOLUTED TUBULE OF THE RABBIT
Author: FIGUEIREDO, JF
FALKENSTEIN, D
Abstract: The inhibition of fluid absorption (Jv) by the antiarrhythmic and antihypertensive drugs propranolol and nifedipine, which increase cytosolic Ca2+ concentration, was studied using the isolated rabbit proximal convoluted tubule perfused in vitro. Proximal convoluted tubules were perfused and bathed with a modified Krebs-Henseleit solution containing bovine serum albumin. Jv was measured after a 30-min control period, after 40 min with either 0.1 mM propranolol or 1.0 mM nifedipine on the peritubular side and after a 40-min recovery period. Both drugs inhibited Jv (58% propranolol, and 21% nifedipine). The 40-min recovery period was sufficient to reverse the effect of nifedipine, but propranolol-treated tubules (N = 6) only reached 78% of the control Jv value. These results demonstrate that antiarrhythmic and antihypertensive drugs are powerful inhibitors of net fluid absorption by exerting a direct effect on proximal or distal tubule cells, thus acting like "locak diuretics".
Subject: PROXIMAL CONVOLUTED TUBULES
PROPRANOLOL
NIFEDIPINE
TUBULE FLUID ABSORPTION
Country: Brasil
Editor: Assoc Bras Divulg Cientifica
Rights: aberto
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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