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|Type:||Artigo de periódico|
|Title:||Neonatal sciatic nerve transection induces TUNEL labeling of neurons in the rat spinal cord and DRG|
|Abstract:||TRANSECTION of a peripheral nerve in neonatal rats induces an extensive death of axotomized neurons. We demonstrate here that spinal motoneurons and sensory dorsal root ganglia neurons become TUNEL-labeled after sciatic nerve transection in neonatal rats, thus indicating that apoptotic mechanisms are involved in the death process. Interestingly, there is also a profound increase of TUNEL-labeled interneurons in the deep dorsal horn. This location suggests that an intact afferent imput and/or contact with target cells is essential for interneuronal survival. Death of motoneurons and sensory neurons could be a result of the injury per se and/or the deprivation of neurotrophic substances, secondary to the loss of contact with target cells.|
|Editor:||Rapid Science Publishers|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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