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Type: Artigo de periódico
Title: Neonatal sciatic nerve transection induces TUNEL labeling of neurons in the rat spinal cord and DRG
Author: Oliveira, ALR
Risling, M
Deckner, M
Lindholm, T
Langone, F
Cullheim, S
Abstract: TRANSECTION of a peripheral nerve in neonatal rats induces an extensive death of axotomized neurons. We demonstrate here that spinal motoneurons and sensory dorsal root ganglia neurons become TUNEL-labeled after sciatic nerve transection in neonatal rats, thus indicating that apoptotic mechanisms are involved in the death process. Interestingly, there is also a profound increase of TUNEL-labeled interneurons in the deep dorsal horn. This location suggests that an intact afferent imput and/or contact with target cells is essential for interneuronal survival. Death of motoneurons and sensory neurons could be a result of the injury per se and/or the deprivation of neurotrophic substances, secondary to the loss of contact with target cells.
Subject: apoptosis
Country: Inglaterra
Editor: Rapid Science Publishers
Citation: Neuroreport. Rapid Science Publishers, v. 8, n. 13, n. 2837, n. 2840, 1997.
Rights: fechado
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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