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Type: Artigo de periódico
Title: Effects of fish oil on lipid profile and other metabolic outcomes in HIV-infected patients on antiretroviral therapy: a randomized placebo-controlled trial
Author: Oliveira, JM
Rondo, PH
Yudkin, JS
Souza, JMP
Pereira, TN
Catalani, AW
Picone, CM
Segurado, AAC
Abstract: Although antiretroviral therapy has revolutionized the care of HIV-infected patients, it has been associated with metabolic abnormalities. Hence, this study was planned to investigate the effects of fish oil on lipid profile, insulin resistance, and body fat distribution in HIV-infected Brazilian patients on antiretroviral therapy, considering that marine omega-3 fatty acids seem to improve features of the metabolic syndrome. We conducted a randomized, parallel, placebo-controlled trial that assessed the effects of 3 g fish oil/day (540 mg of eicosapentaenoic acid plus 360 mg of docosahexaenoic acid) or 3 g soy oil/day (placebo) on 83 HIV-infected Brazilian men and non-pregnant women on antiretroviral therapy. No statistically significant relationships between fish oil supplementation and longitudinal changes in triglyceride (p = 0.335), low- density lipoprotein cholesterol (p = 0.078), high-density lipoprotein cholesterol (p = 0.383), total cholesterol (p = 0.072), apolipoprotein B (p = 0.522), apolipoprotein Al (p = 0.420), low- density lipoprotein cholesterol/ apolipoprotein B ratio (p = 0.107), homeostasis model assessment for insulin resistance index (p = 0.387), body mass index (p = 0.068), waist circumference (p = 0.128), and waist/hip ratio (p = 0.359) were observed. A low dose of fish oil did not alter lipid profile, insulin resistance, and body fat distribution in HIV-infected patients on antiretroviral therapy.
Subject: HIV
metabolic syndrome
lipid profile
insulin resistance
fish oils
omega-3 fatty acids
low-density lipoprotein cholesterol
Country: Inglaterra
Editor: Sage Publications Ltd
Citation: International Journal Of Std & Aids. Sage Publications Ltd, v. 25, n. 2, n. 96, n. 104, 2014.
Rights: fechado
Identifier DOI: 10.1177/0956462413513748
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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