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Type: Artigo de periódico
Title: Effects of Etch-and-Rinse and Self-etch Adhesives on Dentin MMP-2 and MMP-9
Author: Mazzoni, A
Scaffa, P
Carrilho, M
Tjaderhane, L
Di Lenarda, R
Polimeni, A
Tezvergil-Mutluay, A
Tay, FR
Pashley, DH
Breschi, L
Abstract: Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary dentin bonding systems, by the slow action of host-derived matrix metalloproteinases (MMPs). This study tested the null hypothesis that there are no differences in the activities of MMP-2 and -9 after treatment with different etch-and-rinse or self-etch adhesives. Tested adhesives were: Adper Scotchbond 1XT (3M ESPE), PQ1 (Ultradent), Peak LC (Ultradent), Optibond Solo Plus (Kerr), Prime&Bond NT (Dentsply) (all 2-step etch-and-rinse adhesives), and Adper Easy Bond (3M ESPE), Tri-S (Kuraray), and Xeno-V (Dentsply) (1-step self-etch adhesives). MMP-2 and -9 activities were quantified in adhesive-treated dentin powder by means of an activity assay and gelatin zymography. MMP-2 and MMP-9 activities were found after treatment with all of the simplified etch-and-rinse and self-etch adhesives; however, the activation was adhesive-dependent. It is concluded that all two-step etch-and-rinse and the one-step self-etch adhesives tested can activate endogenous MMP-2 and MMP-9 in human dentin. These results support the role of endogenous MMPs in the degradation of hybrid layers created by these adhesives.
Subject: dentin bonding systems
non-collageneous proteins
hybrid layer
biochemical assays
Country: EUA
Editor: Sage Publications Inc
Citation: Journal Of Dental Research. Sage Publications Inc, v. 92, n. 1, n. 82, n. 86, 2013.
Rights: fechado
Identifier DOI: 10.1177/0022034512467034
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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