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Type: Artigo de periódico
Title: Effects of Estrogen Deficiency and/or Caffeine Intake on Alveolar Zone Loss, Density, and Healing: A Study in Rats
Author: Bezerra, JP
de Siqueira, A
Pires, AG
Marques, MR
Duarte, PM
Bastos, MF
Abstract: Background: The aim of this study is to evaluate the effects of caffeine and/or estrogen deficiency on ligature-induced bone loss (BL), trabecular bone area (TBA), and postextraction bone healing (BH). Methods: Rats were assigned into one of the following groups (15 each): 1) control = non-ingestion of caffeine/sham surgery; 2) caffeine = ingestion of caffeine/sham surgery); 3) ovariectomized (OVX) = non-ingestion of caffeine/ovariectomy; or 4) caffeine/OVX = ingestion of caffeine/ovariectomy. The rats were under caffeine administration for 65 days and/or estrogen deficiency for 51 days. On day 21 after ovariectomy, one first mandibular molar received a ligature and the contralateral tooth was not ligated. The first maxillary molars were extracted 8 days before sacrifice. BL, TBA, the positive cells for tartrate-resistant acid phosphatase (TRAP), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) were analyzed in the furcation area of mandibular molars. Histometric BH and gene expression of bone morphogenetic protein (BMP)-2, BMP-7, osteopontin, and bone sialoprotein were evaluated in alveolar sockets. Results: The caffeine group presented the greatest BL and the OVX group the highest number of TRAP-positive (TRAP) cells around ligated teeth (P < 0.05). The control group presented higher TBA and BH than the other groups (P < 0.05). All test groups presented higher RANKL/OPG(+) cells than the control group around ligated/unligated teeth. The OVX and caffeine/OVX groups presented a greater number of TRAP(+) cells around unligated teeth than the control group (P < 0.05). There were no differences among groups for gene expression (P>0.05). Conclusions: Caffeine increased BL in ligated teeth. Caffeine and/or estrogen deficiency decreased TBA in the unligated teeth and reduced BH after tooth extraction.
Subject: Alveolar bone loss
RANK ligand
Country: EUA
Editor: Amer Acad Periodontology
Citation: Journal Of Periodontology. Amer Acad Periodontology, v. 84, n. 6, n. 839, n. 849, 2013.
Rights: fechado
Identifier DOI: 10.1902/jop.2012.120192
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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