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Type: Artigo de periódico
Title: Effects of Bothrops pirajai venom on the mouse extensor digitorum longus (EDL) muscle preparation
Author: Costa, PD
Toyama, MH
Marangoni, S
Rodrigues-Simioni, L
da Cruz-Hofling, MA
Abstract: The effects of Bothrops pirajai snake venom on the mouse extensor digitorum longus (EDL) preparation were examined using myographic, histopathological and biochemical approaches. B, pirajai venom (10, 25 or 50 mu g/ml) dose dependently and irreversibly blocked the contractile response of indirectly stimulated EDL muscle. Histopathological analysis of EDL muscle incubated with venom showed dose-dependent damage with a loss of the normal tissue structure and the appearance of highly dark, edematous fibers together with myofibrils in various stages of condensation. At high doses of venom (50 mu g/ml), loss of muscle cells was observed. In non-stimulated EDL, B, pirajai venom (10 and 50 mu g/ml) caused a time-dependent release of CK which was maximal after 120 min. These results suggest that a component(s) present in the B, pirajai venom has a direct myolytic action on the skeletal muscle. (C) 1999 Elsevier Science Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Toxicon. Pergamon-elsevier Science Ltd, v. 37, n. 8, n. 1143, n. 1153, 1999.
Rights: fechado
Identifier DOI: 10.1016/S0041-0101(98)00250-5
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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