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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffects of an essential oil from the bark of Croton cajucara benth. on experimental gastric ulcer models in rats and micept_BR
dc.contributor.authorHiruma-Lima, CApt_BR
dc.contributor.authorGracioso, JSpt_BR
dc.contributor.authorNunes, DSpt_BR
dc.contributor.authorBrito, ARMSpt_BR
unicamp.authorFund Univ Tocantins, Inst Biol, Porto Nacl, Tocantins, Brazil Univ Estadual Campinas, Dept Farmacol, Fac Ciencias Med, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas, Inst Biol, Dept Fisiol, BR-13081970 Campinas, SP, Brazil Univ Estadual Ponta Grossa, Dept Quim, Ponta Grossa, Parana, Brazilpt_BR
dc.subject.wosMucosal Lesionspt_BR
dc.subject.wosInjurypt_BR
dc.description.abstractCroton cajucara Benth. (Euphorbiaceae) is widely used in Amazonian folk medicine for the treatment of a wide range of gastrointestinal symptoms. The essential oil from its bark was investigated for acute toxicity in mice and for its ability to prevent the formation of ulceration of the gastric mucosa in different models of experimentally induced gastric ulcer in mice and rats. When previously administered orally at a dose of 100 mg kg(-1), the essential oil significantly reduced (P < 0.01) the gastric injury induced by hypothermic restraint stress (48%), indomethacin (47%), ethanol (86%) and pylorus ligature models (87%) in rats. In the HCl/ethanol-induced gastric ulcer model in mice, at oral doses of 100 and 200 mg kg(-1), the essential oil from C. cajucara significantly reduced (P < 0.01) the formation of gastric lesions by 52% and 67%, respectively, when compared with the control group. In rats submitted to pylorus ligature, the essential oil given orally increased the volume of gastric juice when compared with the control group (P < 0.01). When the essential oil (100 mg kg(-1)) was administered intraduodenally to mice, significant modifications were found in gastric parameters such as pH and total acid content after oil treatment. We observed significant changes (P < 0.01) in gastric juice parameters such as an increase in volume and a decrease in gastric acidity (pH and total acid content). The acute toxicologic effects of the essential oil from C. cajucara were assessed in mice. The LD50 values were 9.3 g kg(-1) by the oral route and 680 mg kg(-1) by the intraperitoneal route. The good yield of essential oil obtained from dried C. cajucara bark (1%) as well as its anti-ulcerogenic activity and low toxicity suggest that pharmacological studies of this substance as a potential new anti-ulcerogenic drug are warranted.pt
dc.relation.ispartofJournal Of Pharmacy And Pharmacologypt_BR
dc.relation.ispartofabbreviationJ. Pharm. Pharmacol.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherRoyal Pharmaceutical Soc Great Britainpt_BR
dc.date.issued1999pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationJournal Of Pharmacy And Pharmacology. Royal Pharmaceutical Soc Great Britain, v. 51, n. 3, n. 341, n. 346, 1999.pt_BR
dc.language.isoenpt_BR
dc.description.volume51pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage341pt_BR
dc.description.lastpage346pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0022-3573pt_BR
dc.identifier.wosidWOS:000080229100015pt_BR
dc.identifier.doi10.1211/0022357991772349pt_BR
dc.date.available2014-12-02T16:29:58Z
dc.date.available2015-11-26T17:38:36Z-
dc.date.accessioned2014-12-02T16:29:58Z
dc.date.accessioned2015-11-26T17:38:36Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:38:36Z (GMT). No. of bitstreams: 2 WOS000080229100015.pdf: 86035 bytes, checksum: 63328fffec037ecbb8edbc71ad7bc0c8 (MD5) WOS000080229100015.pdf.txt: 27490 bytes, checksum: 31975e1849206fa959f89fe3836a8333 (MD5) Previous issue date: 1999en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64079pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/64079
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64079-
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