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|Type:||Artigo de periódico|
|Title:||Effect of ultrasound and dexpanthenol on collagen organization in tegumentary lesions|
|Abstract:||Objective: To analyze the effect of ultrasound (US), dexpanthenol (d-P) and a combination of these treatments (US+d-P) on collagen fiber organization in tegumentary lesions in rats by birefringence analysis. Methods: Wistar rats (50) were anesthetized (Thionembutal - Sodic = 50mg/Kg), 1cm(2) of dorsal region skin was removed, and the animals were divided into five groups: control (C), gel (G), US (3 MHz, 0.1 W/cm2, 1 minute, continuous), d-P (10%) and US+d-P. After daily treatment for 7 and 14 days, 6 mu m thick sections of lesioned areas were stained in picrosirius and measurements of the collagen birefringent area (mu m(2)) were obtained using polarized light microscopy (Zeiss Axiolab-ZEISS-Germany) with histological image analysis software (KS 400 2.0 - Kontrol Eletronics, Munique, Germany). The means were compared by ANOVA followed by the Tukey test (p<0.05). Results: The US+d-P group showed a significantly greater (p <= 0.001) birefringent area (1586.43 +/- 162.14) than the other experimental groups: C (139.36 +/- 35.35), US (317.55 +/- 129.9) and d-P (192.41 +/- 3657) by the 7(th) day of treatment, indicating acceleration of the wound healing process. By the 14(th) day of treatment, the US+d-P, US and d-P groups presented greater birefringence than the control group, but did not differ from each other. Conclusion: The combination of treatments (US+d-P) accelerated collagen fiber synthesis and organization in the early stages of cutaneous repair.|
|Editor:||Associacao Brasileira Pesquisa Pos-graduacao Fisioterapia-abrapg-ft|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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