Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63962
Type: Artigo de periódico
Title: EFFECT OF THE PRECURSOR ADDITION ON THE ANTICANCER ALKALOID PRODUCTION USING EXPERIMENTAL DESIGN METHODOLOGY.
Author: Justo, OR
Haber-Perez, V
Viana, CD
Alegre, RM
Abstract: EFFECT OF THE PRECURSOR ADDITION ON THE ANTICANCER ALKALOID PRODUCTION USING EXPERIMENTAL DESIGN METHODOLOGY. The effect of precursors on the anticancer alkaloid production by submerged fermentation using M. anisopliae 3935 was studied, according to complete experimental design 2(2) with three central points. The results showed that lysine was the most important variable, however, when both lysine and glucose were added to the fermentation medium, the alkaloid production reached, approximately, 17 mg L(-1) after 120 hours of fermentation. Then. the scale-up of the process was carried out and these results were confirmed. Finally, 35 mg L(-1) of alkaloid at 192 It were attained after increment of added aminoacid lysine.
Subject: alkaloid
fermentation
M. anisopliae
Country: Brasil
Editor: Soc Brasileira Quimica
Rights: aberto
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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