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Type: Artigo de periódico
Title: Effect of the GABA(B) agonist baclofen on dipyrone-induced delayed gastric emptying in rats
Author: Collares, EF
Vinagre, AM
Abstract: Dipyrone administered intravenously (iv) or intracerebroventricularlv (icv) delays gastric emptying (GE) in rats. Gamma-aminobutyric acid (GABA) is the most potent inhibitory neurotransmitter of the central nervous system. The objective of the present study was to determine the effect of icv; baclofen, a GABA(B) receptor agonist, on delayed GE induced by dipyrone. Adult male Wistar rats received a saline test meal containing phenol red as a marker. GE was indirectly evaluated by; determining the percent of gastric retention (%GR) of the meal 10 min after orogastric administration. In the first esperiment. the animals were injected iv with vehicle (C-iv) or 80 ma/kg (240 mumol/kg) dipyrone (Dp(iv)), followed by icv injection of 10 mul vehicle (bac0), or 0.5 (bac0.5), 1 (bac1) or 2 mug (bac2) baclofen. In the second experiment, the animals were injected icv; with 5 mul vehicle (C-icv) or an equal volume of a solution containing 4 mumol (1333.2 mug) dipyrone (Dp(icv)), followed by 5 mul vehicle (bac0) or 1 mug baclofen (bac1). GE was determined 10 min after icv; injection. There was no significant difference between control animals from one experiment to another concerning GR values. Baclofen at the doses of 1 and 2 mug significantly reduced mean %GR induced by iv dipyrone (Dp(icv)bac1 = 35.9% and Dp(ic)bac2 = 26.9% vs Dp(ic)bac0 = 51.5%). Similarly, baclofen significantly reduced the effect of dipyrone injected i41; (mean %GR: Dp(icv)bac1 = 30.4% vs Dp(ic)bac0 = 54.2%). The present results suggest that dipyrone induces delayed GE through a route in the central nervous system that is blocked by the activation of GABA(B) receptors.
Subject: gastric emptying
GABA(B) receptor
Country: Brasil
Editor: Assoc Bras Divulg Cientifica
Citation: Brazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 38, n. 1, n. 99, n. 104, 2005.
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2005000100015
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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