Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63953
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffect of the GABA(B) agonist baclofen on dipyrone-induced delayed gastric emptying in ratspt_BR
dc.contributor.authorCollares, EFpt_BR
dc.contributor.authorVinagre, AMpt_BR
unicamp.author.emailpediat@fcm.unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Fac Ciencias Med, Dept Pediat, Nucleo Med & Cirugia Expt, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, Fac Ciencias Med, Ctr Invest Pediat, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectgastric emptyingpt_BR
dc.subjectdipyronept_BR
dc.subjectGABApt_BR
dc.subjectGABA(B) receptorpt_BR
dc.subjectBaclofenpt_BR
dc.subject.wosCentral-nervous-systempt_BR
dc.subject.wosDorsal Vagal Complexpt_BR
dc.subject.wosCentral Nucleuspt_BR
dc.subject.wosInsular Cortexpt_BR
dc.subject.wosBinding-sitespt_BR
dc.subject.wosReceptorspt_BR
dc.subject.wosNeuronspt_BR
dc.subject.wosHindbrainpt_BR
dc.subject.wosProjectionspt_BR
dc.subject.wosVaguspt_BR
dc.description.abstractDipyrone administered intravenously (iv) or intracerebroventricularlv (icv) delays gastric emptying (GE) in rats. Gamma-aminobutyric acid (GABA) is the most potent inhibitory neurotransmitter of the central nervous system. The objective of the present study was to determine the effect of icv; baclofen, a GABA(B) receptor agonist, on delayed GE induced by dipyrone. Adult male Wistar rats received a saline test meal containing phenol red as a marker. GE was indirectly evaluated by; determining the percent of gastric retention (%GR) of the meal 10 min after orogastric administration. In the first esperiment. the animals were injected iv with vehicle (C-iv) or 80 ma/kg (240 mumol/kg) dipyrone (Dp(iv)), followed by icv injection of 10 mul vehicle (bac0), or 0.5 (bac0.5), 1 (bac1) or 2 mug (bac2) baclofen. In the second experiment, the animals were injected icv; with 5 mul vehicle (C-icv) or an equal volume of a solution containing 4 mumol (1333.2 mug) dipyrone (Dp(icv)), followed by 5 mul vehicle (bac0) or 1 mug baclofen (bac1). GE was determined 10 min after icv; injection. There was no significant difference between control animals from one experiment to another concerning GR values. Baclofen at the doses of 1 and 2 mug significantly reduced mean %GR induced by iv dipyrone (Dp(icv)bac1 = 35.9% and Dp(ic)bac2 = 26.9% vs Dp(ic)bac0 = 51.5%). Similarly, baclofen significantly reduced the effect of dipyrone injected i41; (mean %GR: Dp(icv)bac1 = 30.4% vs Dp(ic)bac0 = 54.2%). The present results suggest that dipyrone induces delayed GE through a route in the central nervous system that is blocked by the activation of GABA(B) receptors.pt
dc.relation.ispartofBrazilian Journal Of Medical And Biological Researchpt_BR
dc.relation.ispartofabbreviationBrazilian J. Med. Biol. Res.pt_BR
dc.publisher.citySao Paulopt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherAssoc Bras Divulg Cientificapt_BR
dc.date.issued2005pt_BR
dc.date.monthofcirculationJANpt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 38, n. 1, n. 99, n. 104, 2005.pt_BR
dc.language.isoenpt_BR
dc.description.volume38pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage99pt_BR
dc.description.lastpage104pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.wosidWOS:000226663600015pt_BR
dc.identifier.doi10.1590/S0100-879X2005000100015pt_BR
dc.date.available2014-11-18T20:06:19Z
dc.date.available2015-11-26T16:58:26Z-
dc.date.accessioned2014-11-18T20:06:19Z
dc.date.accessioned2015-11-26T16:58:26Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T20:06:19Z (GMT). No. of bitstreams: 1 WOS000226663600015.pdf: 515069 bytes, checksum: 512e12ef3f7336094d9b8ab9010bab9f (MD5) Previous issue date: 2005en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:58:26Z (GMT). No. of bitstreams: 2 WOS000226663600015.pdf: 515069 bytes, checksum: 512e12ef3f7336094d9b8ab9010bab9f (MD5) WOS000226663600015.pdf.txt: 24720 bytes, checksum: 73a8683691ecaa0ca9f411c0bd17e4dc (MD5) Previous issue date: 2005en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63953pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/63953
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63953-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000226663600015.pdf503 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.