Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63921
Type: Artigo de periódico
Title: EFFECT OF GLUCOSE AND K+ DEPOLARIZATION ON CYTOSOLIC FREE CA2+ IN CULTURED NEONATAL ISLETS
Author: BOSCHERO, AC
BORDIN, S
PLASMAN, PO
HERCHUELZ, A
Abstract: In cultured neonatal islet cells, glucose (16.7 mM) and K+ (50 mM) increased cytosolic free Ca2+ ([Ca2+]i). The increments in [Ca2+]i induced by either glucose or K+ were similar to those obtained in cultured adult islet cells but only half of that recorded in freshly isolated adult islet cells. These data indicate that, in neonatal islet cells, the reduced insulin release in response to glucose is associated with a diminished increase in [Ca2+]i. This reduced insulin response may not solely be due to an impaired regulation of the ATP-sensitive K+ channels as previously suggested. It may also result from some alteration in the process of Ca2+ inflow through voltage-sensitive Ca2+ channels.
Subject: PANCREATIC B-CELL
INSULIN RELEASE
NEONATAL ISLETS
CA2+ CHANNELS
CYTOSOLIC FREE CA2+
Country: Alemanha
Editor: Georg Thieme Verlag
Rights: aberto
Identifier DOI: 10.1055/s-2007-1003253
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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