Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63919
Type: Artigo de periódico
Title: EFFECT OF GLUCAGON ON INSULIN-RECEPTOR SUBSTRATE-1 (IRS-1) PHOSPHORYLATION AND ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE (PI-3-KINASE)
Author: SAAD, MJA
HARTMANN, LGC
DECARVALHO, DS
GALORO, CAO
BRENELLI, SL
CARVALHO, CRO
Abstract: In the present study we have examined the levels and phosphorylation state of the insulin receptor and insulin receptor substrate 1 (IRS-1) as well as the association between IRS-I and phosphatidylinositol 3-kinase (PI 3-kinase) in the liver and muscle of rats treated with glucagon, There was a decrease in the insulin-stimulated receptor and IRS-1 phosphorylation levels which was paralleled by a reduced association between IRS-1 and PI 3-kinase in vivo in the liver and muscle of glucagon-treated rats, These observations suggest that glucagon, probably acting through cAMP, may impair insulin signaling in the three early steps in insulin action after binding.
Subject: GLUCAGON
INSULIN RECEPTOR
INSULIN RECEPTOR SUBSTRATE
INSULIN ACTION
TYROSINE KINASE
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/0014-5793(95)00809-N
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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