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|Type:||Artigo de periódico|
|Title:||EFFECT OF GLUCAGON ON INSULIN-RECEPTOR SUBSTRATE-1 (IRS-1) PHOSPHORYLATION AND ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE (PI-3-KINASE)|
|Abstract:||In the present study we have examined the levels and phosphorylation state of the insulin receptor and insulin receptor substrate 1 (IRS-1) as well as the association between IRS-I and phosphatidylinositol 3-kinase (PI 3-kinase) in the liver and muscle of rats treated with glucagon, There was a decrease in the insulin-stimulated receptor and IRS-1 phosphorylation levels which was paralleled by a reduced association between IRS-1 and PI 3-kinase in vivo in the liver and muscle of glucagon-treated rats, These observations suggest that glucagon, probably acting through cAMP, may impair insulin signaling in the three early steps in insulin action after binding.|
INSULIN RECEPTOR SUBSTRATE
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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