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Type: Artigo de periódico
Title: Effect of dose escalation on the tolerability and efficacy of duloxetine in the treatment of women with stress urinary incontinence
Author: Castro-Diaz, D
Palma, PCR
Bouchard, C
Haab, F
Hampel, C
Carone, R
Contreras, SZ
Ginorio, HR
Voss, S
Yalcin, I
Bump, RC
Abstract: To assess the impact of duloxetine dose escalation on tolerability and efficacy, 516 women with stress urinary incontinence were randomized to receive placebo or duloxetine in one of three regimens: 40 mg BID for 8 weeks, 40 mg QD for 2 weeks escalating to 40 mg BID for 6 weeks or 20 mg BID for 2 weeks escalating to 40 mg BID for 6 weeks. A non-inferiority analysis confirmed that the 20 mg BID starting dose was significantly better than the other two duloxetine regimens for nausea reduction (16.5% vs 25.2% and 29.4%). There were also significant differences in the discontinuation rates (7.5% vs 11.8% and 16.2%). The efficacy after 4 weeks was significantly better with duloxetine than with placebo. Starting duloxetine at 20 mg BID for 2 weeks before increasing to 40 mg BID significantly improved tolerability but did not impact duloxetine efficacy after all the subjects had been on 40 mg BID for at least 2 weeks.
Subject: stress urinary incontinence
dose escalation
pharmacological treatment
Country: Inglaterra
Editor: Springer London Ltd
Citation: International Urogynecology Journal. Springer London Ltd, v. 18, n. 8, n. 919, n. 929, 2007.
Rights: fechado
Identifier DOI: 10.1007/s00192-006-0256-x
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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