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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostatept_BR
dc.contributor.authorFavaro, WJpt_BR
dc.contributor.authorCagnon, VHApt_BR
unicamp.author.emailquitete@unicamp.brpt_BR
unicamp.authorFavaro, Wagner J. Cagnon, Valeria H. A. Univ Campinas UNICAMP, Inst Biol, Dept Anat Cellular Biol Physiol & Biophys, BR-13083865 Campinas, SP, Brazilpt_BR
unicamp.authorFavaro, Wagner J. State Univ Sao Paulo UNESP, Dept Anat, Inst Biosci, Botucatu, SP, Brazilpt_BR
dc.subjectdiabetes mellituspt_BR
dc.subjectendostatinpt_BR
dc.subjectIGFR-1pt_BR
dc.subjectinsulinpt_BR
dc.subjectsteroid hormonespt_BR
dc.subjectVEGFpt_BR
dc.subjectventral prostatept_BR
dc.subject.wosRat Prostatept_BR
dc.subject.wosImmunohistochemical Detectionpt_BR
dc.subject.wosVentral Prostatept_BR
dc.subject.wosFactor-betapt_BR
dc.subject.wosFactor-ipt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosAngiogenesispt_BR
dc.subject.wosEndostatinpt_BR
dc.subject.wosVegfpt_BR
dc.description.abstractP>Diabetes causes harmful effects on prostatic morphology and function. However, there still are doubts about the occurrence of various diseases in the prostate, as well as abnormal angiogenesis in relation to diabetes. Thus, the aim of this study was to correlate and quantify the level of the steroid hormone receptors and the angiogenic and antiangiogenic factors in non-obese diabetic mice (Nod) after combined hormonal and insulin therapy. Sixty mice were divided into six groups after 20 days of diabetes: the control group received 0.9% NaCl, as did the diabetic group. The diabetic-insulin group received insulin, the diabetic-testosterone group received testosterone cypionate, the diabetic-oestrogen group received 17 beta-oestradiol, and the diabetic-insulin-testosterone-oestrogen group received insulin, testosterone and oestrogen simultaneously. After 20 days, the ventral lobe was processed for immunocytochemical and hormonal analyses. The results showed that the lowest serum testosterone and androgen receptor levels were found in the diabetic group and the highest testosterone and androgen receptor levels in the diabetic-insulin-testosterone-oestrogen group. The serum oestrogen level and its receptor showed changes opposite to those of testosterone and its receptor. The endostatin reactivity was mainly decreased in diabetic mice. The greatest IGFR-1 and VEGF reactivities occurred in diabetic mice. Thus, diabetes led to the prostatic hormonal imbalance, affecting molecular dynamics and angiogenesis in this organ. Combined insulin and steroid hormone therapy partially restored the hormonal and angiogenic imbalance caused by diabetes.pt
dc.relation.ispartofInternational Journal Of Experimental Pathologypt_BR
dc.relation.ispartofabbreviationInt. J. Exp. Pathol.pt_BR
dc.publisher.cityMaldenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculationDECpt_BR
dc.identifier.citationInternational Journal Of Experimental Pathology. Wiley-blackwell, v. 91, n. 6, n. 537, n. 545, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume91pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage537pt_BR
dc.description.lastpage545pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESP USPpt_BR
dc.identifier.issn0959-9673pt_BR
dc.identifier.wosidWOS:000284589500082pt_BR
dc.identifier.doi10.1111/j.1365-2613.2010.00739.xpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipNational Council for Scientific and Technological Developmentpt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [06/55645-2]pt
dc.date.available2014-11-19T05:16:50Z
dc.date.available2015-11-26T17:57:45Z-
dc.date.accessioned2014-11-19T05:16:50Z
dc.date.accessioned2015-11-26T17:57:45Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:57:45Z (GMT). No. of bitstreams: 2 WOS000284589500082.pdf: 476300 bytes, checksum: 3676b9477ad238f28c778d032ec8d6df (MD5) WOS000284589500082.pdf.txt: 47207 bytes, checksum: a68df85133170d29399a39b7a0669f35 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63821pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/63821
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63821-
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