Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63750
Type: Artigo de periódico
Title: Effect of Anti-Infective Mechanical Therapy on Clinical Parameters and Cytokine Levels in Human Peri-Implant Diseases
Author: Duarte, PM
de Mendonca, AC
Maximo, MBB
Santos, VR
Bastos, MF
Nociti, FH
Abstract: Background: The objectives of this study were to clinically and immunologically assess the effects of mechanical anti-infective therapies for mucositis and peri-implantitis and to compare the levels of cytokines in untreated and treated peri-implant diseased sites to healthy ones. Methods: Titanium dental implants were assigned to one of the following groups: healthy (n = 10) = control; mucositis (n = 10) = mechanical debridement using abrasive sodium carbonate air-powder and resin curets; and peri-implantitis (n = 20) = open surgical debridement using abrasive sodium carbonate air-powder and resin curets. Visible plaque accumulation, marginal bleeding, bleeding on probing, suppuration, and probing depth were assessed at baseline for all groups and at 3 months after therapies for diseased groups. At these times, the total amounts of interleukin (IL)-4, -10, and -12, tumor necrosis factor-alpha (TNF-alpha), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) in the peri-implant crevicular fluid (PICF) were measured by enzyme-linked immunosorbent assay. Results: At 3 months, the anti-infective treatments resulted in a significant improvement in all clinical parameters for mucositis and peri-implantitis (P<0.05). Moreover, the total amounts of TNF-a in PICF were significantly higher in untreated diseased implants compared to healthy ones, and the OPG/RANKL ratio was higher for healthy implants than for untreated peri-implantitis (P<0.05). TNF-a levels were significantly reduced for both diseased groups (P0.05), achieving the same level as the healthy group at 3 months after therapies (P>0.05). Conclusion: The proposed anti-infective therapies may locally modulate the levels of TNF-a and the OPG/RANKL ratio and improve clinical parameters around peri-implant tissues. J Periodontol 2009; 80:234-243.
Subject: Cytokines
dental implants
mucositis
osteoprotegerin
receptor activator of nuclear factor-kappa B ligand
tumor necrosis factor
Country: EUA
Editor: Amer Acad Periodontology
Rights: fechado
Identifier DOI: 10.1902/jop.2009.070672
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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