Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63747
Type: Artigo de periódico
Title: Effect of an NMDA receptor antagonist on the wind-up of neurons in the trigeminal oralis subnucleus
Author: Parada, CA
Luccarini, P
Woda, A
Abstract: Extracellular recordings of convergent neurons of the oralis subnucleus of the trigeminal sensory complex were performed in paralysed rats under halothane-N2O-O-2 anesthesia using glass micropipettes. The effects of MK801, a noncompetitive NMDA receptor antagonist, were observed on the increased cell activity (wind-up), triggered by the repetition, at a low frequency (0.66 Hz) and high intensity (3 times the threshold of C-fiber response), of electrical stimulation of the receptive field. Successive cumulative doses (up to 1 mg/kg) of MK801 i.v. resulted in a dose-dependent decrease in the responses related to C-fiber input (11 cells). A single dose of 1 mg/kg applied in four cells had effects similar to the 1 mg/kg dose given cumulatively. Three units were either weakly or not modified by MK801. In a second experiment, recordings were performed in 12 cells for 80 min after an injection of a small dose of MK801 (0.15 mg/kg). C input was not significantly modified by the antagonist. The effects of MK801 on the first part of the wind-up response (wind-up proper) peaked between 15 and 50 min and returned to control values at about 80 min. The effects on the postdischarge followed approximately the same time course. It is concluded that despite being devoid of substantia gelatinosa, the oralis subnucleus contains neurons that display an NMDA receptor-linked wind-up similar to the phenomenon described in the dorsal horn of the spinal cord. (C) 1997 Elsevier Science B.V.
Subject: rat trigeminal nucleus
oralis subnucleus
wind-up
MK-801
N-methyl-aspartate
nociception
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S0006-8993(97)00355-7
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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