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Type: Artigo de periódico
Title: Effect of additives on the bioreduction of 2-chloro-1-phenyl-2-propen-1-one by baker's yeast
Author: Filho, EPS
Rodrigues, JAR
Moran, PJS
Abstract: The reduction of 2-chloro-1-phenyl-2-propen-1-one (2) by baker's yeast (Saccharomyces cerevisiae) was performed under various reaction conditions, such as the addition of allyl alcohol, sucrose, thermal pre-treatment of the cells and use of a citrate buffer at pH 4.0. 2-Chloro-1-phenyl-1-propan-1-one (3) was produced after 2 h in a poor enantiomeric excess (ee) while after a longer period of fermentation, the compounds IR,2R- and IR,2S-2-chloro-1-phenylpropan-1-ol (4) were obtained at 80-90 and 28-63% ee. (C) 2001 Elsevier Science B.V. All rights reserved.
Subject: alpha-chloropropiophenone
enantio-selective bioreduction
Saccharomyces cerevisiae
allyl alchool
alpha-methylene ketone
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S1381-1177(00)00249-6
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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