Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/63699
Type: Artigo de periódico
Title: Effect of a combined oral contraceptive containing 20 mu g ethinyl estradiol and 75 mu g gestodene on hemostatic parameters
Author: Aldrighp, JM
De Campos, LSC
Gebara, OCE
Petta, CA
Bahamondes, L
Abstract: The effects of a combined oral contraceptive (COC) containing 20 mu g ethinyl estradiol (EE) and 75 mu g gestodene (GSD) on prothrombin activity (PA), activated partial thromboplastin time (APTT), thrombin time (TT), platelet number, fibrinogen, antithrombin III (ATIII), protein C, protein S and D-dimer were evaluated over 6 months in 23 young, healthy women. Laboraton, assessments were performed prior to initiation of COC use (pretreatment) and after 3 and 6 months of use. Results showed no significant changes in fibrinogen, protein C, ATIII or D-dimer during COC use, compared with pretreatment values. The increase in platelet count, decreases in protein S level, PA and APTT, and the prolongation of TT were significant. In conclusion, the use of a COC containing 20 mu g EE and 75 mu g GSD did not cause any significant changes in the hemostatic parameters studied that could be suggestive of a higher prothrombotic risk. Further studies with a larger sample size are necessary in order to obtain conclusive data.
Subject: combined oral hormonal contraceptives
hemostasis
prothrombotic risk
Country: Inglaterra
Editor: Parthenon Publishing Group
Rights: fechado
Identifier DOI: 10.1080/09513590500430328
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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