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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffect of 6 alpha,7 beta-dihydroxyvouacapan-17 beta-oic acid and its lactone derivatives on the growth of human cancer cellspt_BR
dc.contributor.authorEuzebio, FPGpt_BR
dc.contributor.authorSantos, FJLpt_BR
dc.contributor.authorPilo-Veloso, Dpt_BR
dc.contributor.authorRuiz, ALTGpt_BR
dc.contributor.authorde Carvalho, JEpt_BR
dc.contributor.authorFerreira-Alves, DLpt_BR
dc.contributor.authorde Fatima, Apt_BR
unicamp.authorEuzebio, Felipe P. G. dos Santos, Flavio J. L. Pilo-Veloso, Dorila de Fatima, Angelo Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazilpt_BR
unicamp.authorRuiz, Ana Lucia T. G. de Carvalho, Joao Ernesto Univ Estadual Campinas, UNICAMP, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorFerreira-Alves, Dalton L. Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Farmacol, BR-31270901 Belo Horizonte, MG, Brazilpt_BR
dc.subjectPterodon polygalaefloruspt_BR
dc.subjectAntiproliferative activitypt_BR
dc.subject.wosPhotosystem-ii Inhibitorpt_BR
dc.subject.wosRegulatory Activitypt_BR
dc.description.abstractThe furanditerpene 6 alpha,7 beta-dihydroxyvouacapan-17 beta-oic acid (1) is a natural product biosynthesized by some species from the genus Pterodon (Leguminosae). This secondary metabolite has multiple biological activities that include anti-inflammatory, analgesic, plant growth regulatory, anti-edematogenic, photosystem II inhibitory and photosynthesis uncoupler, and antifungal properties. However, few studies on the antiproliferative profile of compound 1 and/or its derivatives have been reported up to date. Here, we describe the isolation of compound 1 from hexane extract of P. polygalaeflorus fruits as well as the semisynthesis of three lactone derivatives: 6 alpha-hydroxyvouacapan-7 beta,17 beta-lactone (2), 6 alpha-acetoxyvouacapan-7 beta,17 beta-lactone (3), and 6-oxovouacapan-7 beta,17 beta-lactone (4). Additionally, antiproliferative activity of these compounds against nine human cancer cell lines was investigated. Our results revealed that 6 alpha-ahydroxyvouacapan-7 beta,17 beta-lactone (2) was the most potent furanditerpene against all cancer cell lines studied. The presence of non-substituted hydroxyl group at C-6 and the presence of 7 beta,17 beta-lactone ring are important for the antiproliferative activity of these compounds. (C) 2009 Elsevier Inc. All rights
dc.relation.ispartofBioorganic Chemistrypt_BR
dc.relation.ispartofabbreviationBioorganic Chem.pt_BR
dc.publisher.citySan Diegopt_BR
dc.publisherAcademic Press Inc Elsevier Sciencept_BR
dc.identifier.citationBioorganic Chemistry. Academic Press Inc Elsevier Science, v. 37, n. 41699, n. 96, n. 100, 2009.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
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